Control of IgE and IgGl antibody production in mice. [X Radiation]

Journal Article · Sat May 01 04:00:00 EDT 1976 · Cell. Immunol.; (United States)

DOI:https://doi.org/10.1016/0008-8749(76)90199-4· OSTI ID:7112540

De Macedo, M S; Braga, F; Mota, I

The production of IgE and IgCl was studied in untreated, thymectomized, splenectomized, anti-thymocyte serum-treated, or sublethally X-irradiated mice. Dinitrophenyl, Ascaris, and ovalbumin were used as antigens, and aluminum hydroxide was used as adjuvant. A suppression of IgE production was observed in adult thymectomized mice, although the kinetic pattern of the antibody response was the same as in control animals. IgGl antibody production was not affected by thymectomy. Splenectomy did not change either IgE or IgGl production. A single dose of rabbit antithymocyte serum (ATS) given 8 days after immunization inhibited IgE antibody production. The effect of ATS was dose dependent and also varied with the amount of antigen used, the immune response to high doses being more susceptible to the effect of ATS. No alteration in IgGl production was caused by ATS even when IgE antibody formation was completely inhibited. When preceding immunization, sublethal irradiation enhanced IgE antibody formation and partially suppressed IgGl production; applied after immunization, irradiation caused an enhancement of IgE production which was inversely proportional to the interval elapsed between the two procedures. On the other hand, the IgGl antibody production was fairly resistant to the same treatment. The results suggest a clearcut separation between the mechanisms regulating IgE and IgGl production in mice.

• Research Organization: Instituto Butantan, Sao Paulo, Brazil
• OSTI ID: 7112540
• Journal Information: Cell. Immunol.; (United States), Journal Name: Cell. Immunol.; (United States) Vol. 23:2; ISSN CLIMB
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBODY FORMATION
AROMATICS
ASCARIS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARBOHYDRATES
CONTROL
DINITROPHENOL
ELECTROMAGNETIC RADIATION
GLOBULINS
GLUCOPROTEINS
HELMINTHS
HYDROXY COMPOUNDS
IMMUNE REACTIONS
IMMUNOGLOBULINS
INVERTEBRATES
IONIZING RADIATIONS
MAMMALS
MEDICINE
MICE
NEMATODES
NITRO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OVALBUMIN
PARASITES
PHENOLS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RODENTS
SACCHARIDES
SPLENECTOMY
SURGERY
THYMECTOMY
VERTEBRATES
X RADIATION