Adjuvant activity of diesel-exhaust particulates for the production of IgE antibody in mice

Journal Article · Tue Apr 01 04:00:00 EST 1986 · J. Allergy Clin. Immunol.; (United States)

DOI:https://doi.org/10.1016/0091-6749(86)90355-6· OSTI ID:5715510

Muranaka, M; Suzuki, S; Koizumi, K; Takafuji, S; Miyamoto, T; Ikemori, R; Tokiwa, H

The prevalence rate of allergic rhinitis caused by pollen has strikingly increased in Japan in the last three decades. The number of diesel cars in use has also rapidly increased in the country. This fact urged us to study the effects of particulates emitted from diesel cars on the production of IgE antibody. The primary IgE antibody responses in mice immunized with intraperitoneal injection of ovalbumin (OA) mixed with diesel-exhaust particulates (DEP) were higher than those in the animals immunized with OA alone. This effect of DEP on the production of IgE antibody in mice was also demonstrated when mice were immunized with repeated injections of dinitrophenylated-OA. In addition, persistent IgE-antibody response to major allergen of Japanese cedar pollen (JCPA), a most common pollen causing allergic rhinitis in Japan, was observed in mice immunized with JCPA mixed with DEP but not in the animals immunized with JCPA alone. The results do indicate that the adjuvant activity of DEP can not be excluded as a possible cause of the associated change in the number of diesel cars and allergic rhinitis caused by pollen in Japan.

• Research Organization: Univ. of Tokyo, Japan
• OSTI ID: 5715510
• Journal Information: J. Allergy Clin. Immunol.; (United States), Journal Name: J. Allergy Clin. Immunol.; (United States) Vol. 4; ISSN JACIB
• Country of Publication: United States
• Language: English

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02 PETROLEUM
020600* -- Petroleum-- Health & Safety
560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALLERGY
ANIMALS
ANTIBODY FORMATION
ASIA
CARBOHYDRATES
DIESEL ENGINES
DISEASES
ENERGY SOURCES
ENGINES
EXHAUST GASES
FLUIDS
FOSSIL FUELS
FUELS
GAMETES
GASEOUS WASTES
GASES
GASOLINE
GERM CELLS
GLUCOPROTEINS
HEAT ENGINES
IMMUNE REACTIONS
INTERNAL COMBUSTION ENGINES
JAPAN
LIQUID FUELS
MAMMALS
MICE
ORGANIC COMPOUNDS
OVALBUMIN
PARTICLES
PARTICULATES
PATHOLOGICAL CHANGES
PETROLEUM
PETROLEUM PRODUCTS
POLLEN
PROTEINS
RESPIRATORY SYSTEM DISEASES
RODENTS
SACCHARIDES
SYNERGISM
TOXICITY
VERTEBRATES
WASTES