Measurements of the distribution of technetium-99m sulfur colloid and technetium-99m HEDP in normal humans

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Med. Phys.; (United States)

DOI:https://doi.org/10.1118/1.595379· OSTI ID:6514465

Grossman, L W; Sodd, V J; Nishiyama, H; Feller, P A; Hoops, R G

Technetium-99m sulfur colloid and technetium-99m hydroxyethylidene diphosphonate (HEDP) are two radiopharmaceuticals that have been widely used in nuclear medicine. Radiation dose estimates for both materials have been published in the literature and are found in the package inserts of the commercial kits. However, these estimates were made without the benefit of quantitative human organ uptake data. Estimates of absorbed radiation dose to the kidneys differ by nearly a factor of 6 between the two calculations for HEDP. The results of this study are in agreement with the lower previous estimate. Other than that one exception, agreement of the previous estimates with the measurements reported here is surprisingly good. Key words: absorbed radiation dose, biological distribution, technetium- 99m HEDP, sulfur colloid

• Research Organization: Nuclear Medicine Laboratory, Division of Electronic Products, Office of Radiological Health, National Center for Devices and Radiological Health, Food and Drug Administration, Cincinnati, Ohio 45267
• OSTI ID: 6514465
• Journal Information: Med. Phys.; (United States), Journal Name: Med. Phys.; (United States) Vol. 10:1; ISSN MPHYA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
BONE MARROW
CALIBRATION
CHALCOGENIDES
COLLOIDS
DIGESTIVE SYSTEM
DISPERSIONS
DOSES
FEMALE GENITALS
GLANDS
GONADS
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LIVER
MALE GENITALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OVARIES
OXYGEN COMPOUNDS
PHOSPHATES
PHOSPHORUS COMPOUNDS
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RETENTION
SPATIAL DOSE DISTRIBUTIONS
SPLEEN
SULFIDES
SULFUR COMPOUNDS
TECHNETIUM 99
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TECHNETIUM PHOSPHATES
TECHNETIUM SULFIDES
TESTES
TISSUES
TRANSITION ELEMENT COMPOUNDS
UPTAKE
YEARS LIVING RADIOISOTOPES