Chromatographic characterization and biological behavior of technetium diphosphonate radiopharmaceuticals

Thesis/Dissertation · Thu Jan 01 04:00:00 EST 1987

OSTI ID:7191022

Schofield, P J

This work describes the characterization of technetium-99m radiopharmaceuticals prepared with the ligand 2,3-dicarboxypropane-1,1 diphosphonate (DPD) and investigations into the biological behavior of other technetium diphosphonate radiopharmaceuticals. The disphosphonate ligands which were used in these studies include: methylene diphosphonate (MDP), 1,1-hydroxyethylidene diphosphonate (HEDP), dimethylaminomethylene diphosphonate (DMAD) and DPD. The sodium borohydride reduced technetium-99m dicarboxypropane diphosphonate (/sup 99m/Tc(NaBH/sub 4/)-DPD) radiopharmaceutical preparations were characterized and separated by anion exchange high performance liquid chromatography (HPLC). Several parameters important to the formulation of these /sup 99m/Tc-DPD radiopharmaceuticals were varied, including pH, presence or absence of atmospheric oxygen, concentration of technetium, and time post reaction.

• Research Organization: Cincinnati Univ., OH (USA)
• OSTI ID: 7191022
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
CHEMICAL COMPOSITION
CHEMICAL PREPARATION
CHROMATOGRAPHY
DRUGS
ISOMERIC NUCLEI
LABELLED COMPOUNDS
LIGANDS
LIQUID COLUMN CHROMATOGRAPHY
NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHONATES
RADIOPHARMACEUTICALS
REFRACTORY METAL COMPOUNDS
SEPARATION PROCESSES
SYNTHESIS
TECHNETIUM COMPOUNDS
TRANSITION ELEMENT COMPOUNDS