Brain damage from sup 125 I brachytherapy evaluated by MR imaging, a blood-brain barrier tracer, and light and electron microscopy in a rat model

Journal Article · Mon Oct 01 04:00:00 EDT 1990 · Journal of Neurosurgery; (USA)

DOI:https://doi.org/10.3171/jns.1990.73.4.0585· OSTI ID:6508859

Bernstein, M; Marotta, T; Stewart, P; Glen, J; Resch, L; Henkelman, M ^[1]

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1. Toronto Western Hospital, Ontario (Canada)

Changes in normal rat brain were studied acutely, and at 3, 6, 9, and 12 months following interstitial brachytherapy with high-activity {sup 125}I seeds. An 80-Gy radiation dose was administered to an area with a 5.5-mm radius. Effects were measured with magnetic resonance (MR) imaging (with and without gadolinium enhancement), leakage of horseradish peroxidase (HRP), electron microscopy, and light microscopy. Significant histological damage was seen at radiation doses above 295 Gy, and breakdown of the blood-brain barrier was observed only in tissue receiving a dose of 165 Gy or greater. Blood-brain barrier breakdown increased up to the 6-month time point, and thereafter appeared to stabilize or decrease. The area of blood-brain barrier disruption indicated by gadolinium-enhanced MR imaging was greater than that indicated by leakage of HRP.

• OSTI ID: 6508859
• Journal Information: Journal of Neurosurgery; (USA), Journal Name: Journal of Neurosurgery; (USA) Vol. 73:4; ISSN 0022-3085; ISSN JONSA
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD-BRAIN BARRIER
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOSES
ELECTRON CAPTURE RADIOISOTOPES
ENZYMES
IMPLANTS
INJURIES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
MAGNETIC RESONANCE
MEDICINE
NERVOUS SYSTEM
NMR IMAGING
NUCLEAR MAGNETIC RESONANCE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXIDOREDUCTASES
PEROXIDASES
RADIATION DOSES
RADIATION EFFECTS
RADIATION INJURIES
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RESONANCE
SIDE EFFECTS
THERAPY