MR of brain radiation injury: experimental studies in cats
Journal Article
·
· AJNR, Am. J. Neuroradiol.; (United States)
OSTI ID:6321893
Two of six cats receiving small-field, single-dose, brain irradiation of 35 Gy with 6 MeV photons developed brain abnormalities in the irradiated area on MR images at 6 and 8 months, respectively, after treatment. The lesions were of high intensity on T2-weighted images and did not enhance after IV administration of gadolinium-DTPA. An additional lesion in one of these cats displayed high signal on T2-weighted images and enhanced on T1-weighted images after IV gadolinium-DTPA. Pathologic correlation revealed that the nonenhancing T2-weighted lesions consisted of edema or demyelinated regions without inflammation while the gadolinium-enhanced lesion demonstrated necrosis with inflammatory infiltrate. Focal brain irradiation may produce noninflammatory demyelination and necrosis. These histologic entities may be potentially distinguished on MR with IV gadolinium-DTPA.
- Research Organization:
- Hospital of the Univ. of Pennsylvania, Philadelphia
- OSTI ID:
- 6321893
- Journal Information:
- AJNR, Am. J. Neuroradiol.; (United States), Journal Name: AJNR, Am. J. Neuroradiol.; (United States) Vol. 8:3; ISSN AAJND
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550600 -- Medicine
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CARBOXYLIC ACIDS
CATS
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
DIAGNOSTIC TECHNIQUES
DRUGS
DTPA
GADOLINIUM COMPOUNDS
MAGNETIC RESONANCE
MAMMALS
NECROSIS
NERVOUS SYSTEM
NMR IMAGING
NUCLEAR MAGNETIC RESONANCE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOPROTECTIVE SUBSTANCES
RARE EARTH COMPOUNDS
RESONANCE
VERTEBRATES
560152* -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CARBOXYLIC ACIDS
CATS
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
DIAGNOSTIC TECHNIQUES
DRUGS
DTPA
GADOLINIUM COMPOUNDS
MAGNETIC RESONANCE
MAMMALS
NECROSIS
NERVOUS SYSTEM
NMR IMAGING
NUCLEAR MAGNETIC RESONANCE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOPROTECTIVE SUBSTANCES
RARE EARTH COMPOUNDS
RESONANCE
VERTEBRATES