Experimental radiation injury: combined MR imaging and spectroscopy

Journal Article · Tue Nov 01 04:00:00 EST 1988 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.169.2.3174977· OSTI ID:6867913

Grossman, R I; Hecht-Leavitt, C M; Evans, S M; Lenkinski, R E; Holland, G A; Van Winkle, T J; McGrath, J T; Curran, W J; Shetty, A; Joseph, P M

A model of radiation injury to the brain was developed in the cat. Definite radiation changes were demonstrated at magnetic resonance (MR) imaging in four of six cats. These changes consisted of high-intensity abnormalities on images obtained with a long repetition time (TR) and a long echo time (TE), which were initially noted 208-285 days after irradiation. These changes were associated with gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) enhancement on short TR and inversion-recovery (IR) pulse sequences. Gd-DTPA enhancement and the high intensity on the long TR/TE images were identified at the same time and became more prominent throughout the study. Chemical-shift imaging and phosphorus spectroscopy demonstrated no notable changes despite clear-cut MR evidence of abnormalities. Sodium imaging was positive in one case. Correlation of MR and pathologic findings revealed areas of radiation necrosis and wallerian degeneration that corresponded to areas of Gd-DTPA enhancement on short TR and IR images and to areas of high intensity on long TR/TE images. Peripheral to the areas of Gd-DTPA enhancement were nonenhanced zones of high-signal-intensity abnormality on long TR/TE images, which represented regions of demyelination without necrosis. Gd-DTPA-enhanced proton imaging was the most sensitive method for detecting radiation damage in this animal model.

• Research Organization: Univ. of Pennsylvania, Philadelphia (USA)
• OSTI ID: 6867913
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 169:2; ISSN RADLA
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CARBOXYLIC ACIDS
CATS
CENTRAL NERVOUS SYSTEM
CHELATING AGENTS
CHEMICAL SHIFT
CONTRAST MEDIA
DIAGNOSTIC TECHNIQUES
DRUGS
DTPA
IMAGE PROCESSING
INJURIES
MAGNETIC RESONANCE
MAMMALS
NECROSIS
NERVOUS SYSTEM
NMR IMAGING
NUCLEAR MAGNETIC RESONANCE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PROCESSING
RADIATION EFFECTS
RADIATION INJURIES
RADIOPROTECTIVE SUBSTANCES
RESONANCE
SENSITIVITY ANALYSIS
SPECTROSCOPY
VERTEBRATES