Acute myocardial ischemia and reperfusion: MR imaging with albumin-Gd-DTPA

Journal Article · Wed Feb 01 04:00:00 EST 1989 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.170.2.2911657· OSTI ID:6499842

Schmiedl, U; Sievers, R E; Brasch, R C; Wolfe, C L; Chew, W M; Ogan, M D; Engeseth, H; Lipton, M J; Moseley, M E

The utility of a macromolecular, intravascular contrast agent, albumin-gadolinium diethylenetriaminepentaacetic acid (DTPA), for the differentiation of acutely ischemic and reperfused myocardium on magnetic resonance (MR) images was investigated. Regional, reversible myocardial ischemia was produced in rats and confirmed. After reperfusion, flow to the compromised myocardial segment returned to baseline. Normal myocardium could not be differentiated from ischemic myocardium on nonenhanced MR images (n = 12). After 5 minutes of myocardial ischemia and after administration of albumin-Gd-DTPA, the ischemic zone involving the free wall of the left ventricle was characterized by the absence of significant enhancement. Normal myocardium appeared homogeneously enhanced (by 145%). This pattern persisted for up to 1 hour of myocardial ischemia. In six rats that underwent myocardial reperfusion after 5 minutes of ischemia, the normal and reperfused myocardium became isointense. Radiotracer studies with albumin-Gd-153-DTPA confirmed the decreased distribution of contrast agent to the ischemic myocardium, possibly due to decreased blood pool or a blocked primary delivery system in the ischemic myocardium.

• Research Organization: Univ. of California School of Medicine, San Francisco (USA)
• OSTI ID: 6499842
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 170:2; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHELATING AGENTS
CONTRAST MEDIA
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GADOLINIUM 153
GADOLINIUM ISOTOPES
HEART
INTERMEDIATE MASS NUCLEI
ISCHEMIA
ISOTOPES
MAMMALS
MICROSPHERES
MUSCLES
MYOCARDIUM
NMR IMAGING
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
ORGANS
PERFUSED TISSUES
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RATS
RODENTS
TISSUES
VASCULAR DISEASES
VERTEBRATES