Ischemia-induced local release of myocardial noradrenaline

Journal Article · Tue Jan 01 04:00:00 EST 1985 · J. Cardiovasc. Pharmacol.; (United States)

DOI:https://doi.org/10.1097/00005344-198500075-00005· OSTI ID:5018720

Abrahamsson, T; Almgren, O; Carlsson, L

The isolated perfused rat heart, prelabelled with /sup 3/H-noradrenaline (NA), was used to examine the ischemia-induced release of myocardial NA, and to investigate to what extent reperfusion of an ischemic myocardium per se causes a release of NA. In a model of global myocardial ischemia with 90% flow reduction and the use of lactate as perfusion substrate, release of /sup 3/H-NA into the perfusate was already observed during the first 10-20 min of ischemia. The quantities of /sup 3/H-NA released increased further with increasing duration of ischemia. In another model with regional ischemia produced by left coronary artery ligation, a similar, though less marked, release of /sup 3/H-NA into the perfusate was observed during ischemia. Reperfusion after 60 min of ischemia was associated with a marked outflow of /sup 3/H-NA and /sup 3/H-NA metabolites, which was not reduced if reperfusion was performed with a Ca2+-free buffer. Furthermore, in the globally ischemic heart model, the relative amounts of /sup 3/H-NA and the various /sup 3/H-NA metabolites in the effluent remained constant during the last minute of ischemia and the first minute of reperfusion. The authors concluded that ischemia is associated with early local release of myocardial NA. NA can partly be trapped in the ischemic tissue and washed out during reperfusion.

• Research Organization: Haessle Cardiovascular Research Labs., Moelndal, Sweden
• OSTI ID: 5018720
• Journal Information: J. Cardiovasc. Pharmacol.; (United States), Journal Name: J. Cardiovasc. Pharmacol.; (United States); ISSN JCPCD
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ANIMALS
ARTERIES
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEMICAL REACTIONS
CORONARIES
DECOMPOSITION
DISEASES
DRUGS
GLYCOLYSIS
HEART
HORMONES
ISCHEMIA
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
METABOLITES
MUSCLES
MYOCARDIUM
NEUROREGULATORS
NORADRENALINE
ORGANS
PERFUSED ORGANS
RATS
RODENTS
STEROID HORMONES
SUBSTRATES
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VASCULAR DISEASES
VERTEBRATES