Detection of myocardial ischemia before infarction, based on accumulation of labeled pyruvate

Conference · Fri Oct 31 23:00:00 EST 1980 · J. Nucl. Med.; (United States)

OSTI ID:7059898

Goldstein, R A; Klein, M S; Sobel, B E

To determine whether ischemic, but not irreversibly injured myocardium, can be differentiated from normal tissue based on accumulation of labeled pyruvate, isolated hearts were perfused with buffer containing (/sup 14/C)pyruvate under conditions of normal or low flow. Fifteen minutes after the hearts were exposed to labeled material, myocardial radioactivity was fourfold greater in ischemic compared to control hearts, due to accumulation of label in sequestered lactate produced from the pyruvate. Open-chest rabbits subjected to coronary occlusion exhibited a 1.73:1 ratio of radioactivity in ischemic compared with normal myocardium 15 min after systemic injection of (/sup 14/C)pyruvate. The results obtained suggest that zones of myocardial ischemia should be detectable in vivo by positron tomography after systemic administration of (/sup 11/C)pyruvate as well.

• Research Organization: Washington Univ., St. Louis, MO
• OSTI ID: 7059898
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:11; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL TISSUES
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BLOOD CIRCULATION
BLOOD VESSELS
BODY
CARBON 11
CARBON 14 COMPOUNDS
CARBON ISOTOPES
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CORONARIES
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ESTERS
EVEN-ODD NUCLEI
HEART
ISCHEMIA
ISOTOPES
KETO ACIDS
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
MYOCARDIAL INFARCTION
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PERFUSED TISSUES
PYRUVIC ACID
RABBITS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TIME DEPENDENCE
TISSUES
TOMOGRAPHY
USES
VASCULAR DISEASES
VERTEBRATES