Halothane inhibits calcium accumulation following myocardial ischemia and calcium paradox in guinea pig hearts

Journal Article · Sat Aug 01 04:00:00 EDT 1987 · Anesthesiology; (United States)

DOI:https://doi.org/10.1097/00000542-198708000-00008· OSTI ID:6274847

Hoka, S; Bosnjak, Z J; Kampine, J P

This study was performed to test the hypothesis that halothane inhibits calcium accumulation associated with myocardial ischemia and calcium paradox. Using a Langendorff preparation in isolated guinea pig hearts, tissue /sup 45/Ca was measured after 40 and 60 min of loading with /sup 45/Ca, followed by 20 min of washout period. Myocardial ischemia was produced by a 30-min occlusion of the left anterior descending coronary artery (LAD). LAD occlusion caused an increase in /sup 45/Ca content in the anterior left ventricular muscle (ischemic area) of 215% compared to that of the posterior left ventricular muscle (normal myocardium). The increase in /sup 45/Ca content in the ischemic area was significantly less (P less than 0.05) in the presence of halothane (1%) compared to the non-halothane group. Halothane did not significantly alter /sup 45/Ca content in the non-ischemic myocardium. Myocardial injury associated with calcium paradox, which was produced by a 10-min perfusion of the heart with calcium-free Krebs solution followed by normal calcium repletion, caused a significant increase (P less than 0.05) in the /sup 45/Ca content compared to control. Addition of halothane (1%) significantly depressed (P less than 0.05) the increase in /sup 45/Ca content caused by calcium paradox. It is suggested that halothane might inhibit calcium accumulation associated with myocardial ischemia and calcium paradox under certain experimental situations. The inhibitory effect of halothane on calcium accumulation may be beneficial for the ischemic heart during halothane anesthesia.

• Research Organization: Medical College of Wisconsin, Milwaukee
• OSTI ID: 6274847
• Journal Information: Anesthesiology; (United States), Journal Name: Anesthesiology; (United States) Vol. 67:2; ISSN ANESA
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METALS
ANESTHESIA
ANESTHETICS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BODY
CALCIUM
CALCIUM 45
CALCIUM ISOTOPES
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELEMENTS
EVEN-ODD NUCLEI
GUINEA PIGS
HEART
INHIBITION
INTERMEDIATE MASS NUCLEI
ISCHEMIA
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METALS
MUSCLES
MYOCARDIUM
NUCLEI
ORGANS
PATHOGENESIS
PERFUSED ORGANS
RADIOISOTOPES
RODENTS
TRACER TECHNIQUES
VASCULAR DISEASES
VERTEBRATES