MR assessment of radiation-induced blood-brain barrier permeability changes in a rat glioma model

Journal Article · Fri Apr 01 04:00:00 EST 1994 · AJNR. American Journal of Neuroradiology; (United States)

OSTI ID:6757995

Krueck, W G ^[1]; Schmiedl, U P; Maravilla, K R; Starr, F L; Kenney, J ^[2]

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1. Univ. of Tuebingen School of Medicine (Germany) Univ. of Washington School of Medicine, Seattle, WA (United States)
2. Univ. of Washington School of Medicine, Seattle, WA (United States)

To assess the potential of a T1-weighted, gadolinium-enhanced MR technique for quantifying radiation-induced changes of blood-brain barrier permeability in a model of stereotactically implanted intracerebral gliomas in rats. We calculated the gadolinium blood-to-tissue transport coefficient for gadopentetate dimeglumine from signal intensities in sequential MR images in nine control animals that were not irradiated and in five and three animals that had received 2500 cGy and 1500 cGy whole-brain irradiation, respectively, at 2 days before imaging. The average blood-to-tissue transport coefficient values were 9.76 mL[center dot]kg[sup [minus]1][center dot]min[sup [minus]1] in the control group, 23.41 mL[center dot]kg[sup [minus]1][center dot]min[sup [minus]1] in the 2500-cGy group, and 25.63 mL[center dot]kg[sup [minus]1][center dot]min[sup [minus]1] in the 1500-cGy group. Blood-to-tissue transport coefficients were significantly higher after irradiation, indicating increased radiation-induced blood-brain barrier permeability. Similar increased blood-brain barrier leakiness in brain tumors after high-dose irradiation has been shown by previous nuclear medicine studies using quantitative autoradiography. Contrast-enhanced dynamic MR of brain gliomas is a sensitive method to document radiation-induced blood-brain barrier breakdown. Quantitative gadolinium-enhanced MR may become a useful tool for the management of patients with brain tumors undergoing radiation therapy. 28 refs., 4 figs., 1 tab.

• OSTI ID: 6757995
• Journal Information: AJNR. American Journal of Neuroradiology; (United States), Journal Name: AJNR. American Journal of Neuroradiology; (United States) Vol. 15:4; ISSN 0195-6108; ISSN AAJNDL
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
560152 -- Radiation Effects on Animals-- Animals
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD-BRAIN BARRIER
BODY
BRAIN
BREAKDOWN
CENTRAL NERVOUS SYSTEM
DISEASES
ELEMENTS
GADOLINIUM
GLIOMAS
IRRADIATION
MAGNETIC RESONANCE
MAMMALS
MEDICINE
METALS
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
PERMEABILITY
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
RARE EARTHS
RATS
RESONANCE
RODENTS
THERAPY
VERTEBRATES