Mechanisms for radiation damage in DNA. Progress report, January 1, 1980-December 31, 1980

Technical Report · Mon Sep 01 04:00:00 EDT 1980

DOI:https://doi.org/10.2172/6501243· OSTI ID:6501243

Sevilla, M D

In this project several mechanisms are proposed for radiation damage to DNA constituents and DNA, and a series of experiments detailed utilizing electron spin resonance spectrometry to test the proposed mechanisms. Under current investigation are irradiated systems of DNA constituents which may shed light on indirect effects. In addition, studies of radiation effects on lipids have been undertaken which will shed light on the only other proposed site for cell kill, the membrane. Studies completed during the past year are: (1) ..pi.. cations produced in DNA bases by attack of oxidizing radicals; (2) INDO studies of radicals produced in peptides and carboxylic acid model compounds; (3) electron reactions with carboxylic acids, ketones and aldehydes; and (4) ..gamma..-irradiation of esters and triglycerides. Progress has been made this year in a study of radicals generated in model compounds for the sugar-phosphate backbone.

• Research Organization: Oakland Univ., Rochester, MI (USA)
• Sponsoring Organization: USDOE
• DOE Contract Number: AS02-76EV02364
• OSTI ID: 6501243
• Report Number(s): DOE/EV/02364-T1; COO-2364-18
• Country of Publication: United States
• Language: English

Related Subjects

560111* -- Radiation Effects on Biochemicals-- In Vitro-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CATIONS
CELL CONSTITUENTS
CELL MEMBRANES
CHARGED PARTICLES
CHEMICAL REACTIONS
DNA
ELECTRON SPECTROSCOPY
ELECTRON SPIN RESONANCE
HYDROXYL RADICALS
INJURIES
IONS
LIPIDS
MAGNETIC RESONANCE
MEMBRANES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATION INJURIES
RADICALS
RESEARCH PROGRAMS
RESONANCE
SPECTROSCOPY