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Mechanisms for radiation damage in DNA

Technical Report ·
OSTI ID:6646571
Several mechanisms are proposed for radiation damage to DNA and its constituents, and a series of experiments utilizing electron spin resonance spectrometry have been used to test the proposed mechanisms. In the past we have concentrated chiefly on investigating irradiated systems of DNA constituents. In this year's effort we have concentrated on radiation effects on DNA itself. In addition studies of radiation effects on lipids and model compounds have been performed which shed light on the only other proposed site for cell kill, the membrane.
Research Organization:
Oakland Univ., Rochester, MI (USA). Dept. of Chemistry
DOE Contract Number:
FG02-86ER60455
OSTI ID:
6646571
Report Number(s):
DOE/ER/60455-1; ON: DE87008311
Country of Publication:
United States
Language:
English

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Related Subjects

560100* -- Biomedical Sciences
Applied Studies-- Radiation Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHEMISTRY
DNA
ELECTROMAGNETIC RADIATION
ELECTRON SPIN RESONANCE
GAMMA RADIATION
IONIZING RADIATIONS
LIPIDS
MAGNETIC RESONANCE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
OXYGEN ENHANCEMENT RATIO
RADIATION CHEMISTRY
RADIATIONS
RADICALS
RESONANCE
THIYL RADICALS