Mechanisms for radiation damage in DNA. Progress report
Technical Report
·
OSTI ID:5319847
In this project we have proposed several mechanisms for radiation damage to DNA and its constituents, and have detailed a series of experiments utilizing electron spin resonance spectrometry to test the proposed mechanisms. In the past we have concentrated chiefly on investigating irradiated systems of DNA constituent. In this past year's effort we have concentrated on radiation effects on DNA itself. In addition studies of radiation effects on lipids and model compounds have been performed which will shed light on the only other proposed site for cell kill, the membrane. 8 refs., 4 figs.
- Research Organization:
- Oakland Univ., Rochester, MI (USA)
- DOE Contract Number:
- AC02-76EV02364
- OSTI ID:
- 5319847
- Report Number(s):
- DOE/EV/02364-21; ON: DE85017473
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400600* -- Radiation Chemistry
560110 -- Radiation Effects on Biochemicals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CELL CONSTITUENTS
CELL MEMBRANES
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
DERIVATIZATION
DNA
ELECTROMAGNETIC RADIATION
ELECTRON SPIN RESONANCE
GAMMA RADIATION
HUMIDITY
IONIZING RADIATIONS
LIPIDS
LIPOSOMES
MAGNETIC RESONANCE
MEMBRANES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANOIDS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RESONANCE
400600* -- Radiation Chemistry
560110 -- Radiation Effects on Biochemicals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CELL CONSTITUENTS
CELL MEMBRANES
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
DERIVATIZATION
DNA
ELECTROMAGNETIC RADIATION
ELECTRON SPIN RESONANCE
GAMMA RADIATION
HUMIDITY
IONIZING RADIATIONS
LIPIDS
LIPOSOMES
MAGNETIC RESONANCE
MEMBRANES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANOIDS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADIATIONS
RESONANCE