Radiation carcinogenesis. Comprehensive final report, 16 May 1979-31 December 1980
This abstract covers three main areas of investigation: mesothelioma induction by asbestos, radiation tumorigenesis and transplantable tumors. Canadian and Rhodesian asbestos fibers have been administered under anesthesia to rats by intratracheal, intrapleural and intraperitoneal injection. Additional groups were given 3-methylcholanthrene or x-radiation along with asbestos. A large series of mice also treated as above have displayed mesotheliomas. In addition, glass fiber injections and feeding of asbestos were done and have produced negative results to date. The carcinogenic effect of whole-body radiation on hemi-irradiated parabiont partners exposed to a single 1000 R dose of x-ray was evidenced by a significant increase in the incidence of malignant tumors in only six tissues: skin, supporting soft tissue, kidney, bone, pancreatic islets and ovary. In the male adrenal medulla and in the female breast genetic and parabiotic hormonal factors were judged to exert a significant effect. The occurrence of incisional (anastomotic) sarcomas in significant numbers in hemi-irradiated and parabiont control pairs suggests the operation of mechanical factors complicating the healing process, only slightly enhanced by radiation. One of the very valuable but unanticipated developments of the rat radiation program was the isolation of two transplantable endocrine tumors with strong hormonal potentials: an insulinoma of the pancreas and a pheochromocytoma of the adrenal medulla.
- Research Organization:
- New England Deaconess Hospital, Boston, MA (USA). Cancer Research Inst.
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AS02-76EV03017
- OSTI ID:
- 6495703
- Report Number(s):
- DOE/EV/03017-43
- Country of Publication:
- United States
- Language:
- English
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560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ASBESTOS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOGENESIS
DATA
DISEASES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
INFORMATION
INJECTION
INTAKE
IONIZING RADIATIONS
IRRADIATION
MAMMALS
MICE
NEOPLASMS
NUMERICAL DATA
PATHOGENESIS
RADIATION EFFECTS
RADIATIONS
RATS
RODENTS
SUPRALETHAL IRRADIATION
SYNERGISM
TRANSPLANTS
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION