Mesothelioma relative to asbestos, radiation, and methylcholanthrene. [Rats; x-ray]

Journal Article · Mon Jun 01 04:00:00 EDT 1981 · Arch. Pathol. Lab. Med.; (United States)

OSTI ID:6231831

Warren, S; Brown, C E; Chute, R N; Federman, M

The carcinogenicity of chrysotile asbestos fibers (Canadian and Rhodesian) for the mesothelium of pleura and peritoneum of NEDH rats was explored by injection of 2 mg of asbestos fibers suspended in saline intratracheally, intrapleurally, or intraperitoneally, with or without ancillary radiation treatment, or alternatively, by injection of asbestos plus 1 mg of 3-methylcholanthrene. A highly significant incidence of mesothelioma (3.8%) was noted in 159 rats treated with asbestos alone, as compared with 0.1% in 1417 control rats. Additional treatment with radiation or 3-methylcholanthrene increased this incidence to 11.8% and 25.5%, respectively.

• Research Organization: New England Deaconess Hospital, Boston, MA
• OSTI ID: 6231831
• Journal Information: Arch. Pathol. Lab. Med.; (United States), Journal Name: Arch. Pathol. Lab. Med.; (United States) Vol. 105:6; ISSN APLMA
• Country of Publication: United States
• Language: English

Related Subjects

3-METHYLCHOLANTHRENE
560152* -- Radiation Effects on Animals-- Animals
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
AROMATICS
ASBESTOS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
DELAYED RADIATION EFFECTS
DISEASES
ELECTROMAGNETIC RADIATION
EPITHELIUM
EXTERNAL IRRADIATION
HISTOLOGY
HYDROCARBONS
IONIZING RADIATIONS
IRRADIATION
LUNGS
MAMMALS
MEMBRANES
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PARTIAL BODY IRRADIATION
PATHOGENESIS
PERITONEUM
PLEURA
POLYCYCLIC AROMATIC HYDROCARBONS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RATS
RESPIRATORY SYSTEM
RODENTS
SEROUS MEMBRANES
TISSUES
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION