Comparative mesothelioma induction in rats by asbestos and non-asbestos mineral fibers: possible correlation with human-exposure data

Technical Report · Mon Aug 01 04:00:00 EDT 1988

OSTI ID:6648329

Coffin, D L; Palekar, L D; Cook, P M; Creason, J P

Fischer 344 rats were injected intrapleurally with chrysotile and crocidolite asbestos, erionite and attapulgite and observed for their entire lifespan. Detailed analysis of the number per unit mass of the various size categories of the fibers for each mineral species was determined and the dose in terms of actual number of mineral fibers computed. Data for survival time and number of tumors induced suggests that in addition to the length/width factors, an additional property plays a role in fiber potency. Analysis of the available data from the literature, where populations were known to have been exposed to pure mineral fibers, indicates that ranking for human mesothelioma incidence appears congruent with the rat intrapleural data.

• Research Organization: Northrop Services, Inc., Research Triangle Park, NC (USA)
• OSTI ID: 6648329
• Report Number(s): PB-88-250246/XAB
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ASBESTOS
ATTAPULGITE
BIOLOGICAL ACCUMULATION
BODY
CLAYS
CORRELATIONS
DISEASES
ENVIRONMENTAL EXPOSURE
EPITHELIUM
FIBERS
HAZARDOUS MATERIALS
LABORATORY ANIMALS
MATERIALS
MINERALS
NEOPLASMS
TISSUES
TOXICITY