Mesothelioma relative to asbestos, radiation, and methylcholanthrene

Journal Article · Mon Jun 01 04:00:00 EDT 1981 · Arch. Pathol. Lab. Med.; (United States)

OSTI ID:5634869

Warren, S; Brown, C E; Chute, R N; Federman, M

The carcinogenicity of chrysotile asbestos fibers (Canadian and Rhodesian) for the mesothelium of pleura and peritoneum of NEDH rats was explored by injection of 2 mg of asbestos fibers suspended in saline intratracheally, intrapleurally, or intraperitoneally, with or without ancillary radiation treatment (1,000 rad to the whole body of parabiont rats or 2,000 rad to the right thorax of single rats), or alternatively, by injection of asbestos plus 1 mg of 3-methylcholanthrene. A highly significant incidence of mesothelioma (3.8%) was noted in 159 rats treated with asbestos alone, as compared with 0.1% in 1,417 control rats. Additional treatment with radiation or 3-methylcholanthrene increased this incidence to 11.8% and 25.5%, respectively, the latter increase alone being significant at the .01 level of probability.

• OSTI ID: 5634869
• Journal Information: Arch. Pathol. Lab. Med.; (United States), Journal Name: Arch. Pathol. Lab. Med.; (United States) Vol. 105:6; ISSN APLMA
• Country of Publication: United States
• Language: English

Related Subjects

550900 -- Pathology
560152 -- Radiation Effects on Animals-- Animals
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
ASBESTOS
BODY
CHOLANTHRENE
CONDENSED AROMATICS
DISEASES
DOSES
EXTERNAL IRRADIATION
IRRADIATION
LUNGS
MAMMALS
MEMBRANES
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGY
PLEURA
RADIATION DOSES
RADIOSENSITIVITY EFFECTS
RATS
RESPIRATORY SYSTEM
RODENTS
SENSITIVITY
SEROUS MEMBRANES
TOXICITY
VERTEBRATES
WHOLE-BODY IRRADIATION