Radiation carcinogenesis. Progress report VI, 16 May 1978--15 May 1979
Asbestos fibers, Canadian and Rhodesian chrysotile, have induced mesotheliomas and pleural plaques in mice and rats. The pathogenesis of the lesions is being studied. Proliferation of the adrenal cortical A cells is accelerated in time and enhanced in extent by ionizing radiation in female RAP mice. The development of cortical tumors was significantly correlated with extensive A cell proliferation. Whole-body protracted doses, above 500 rads, were followed by a 9% tumor incidence. Endocrine neoplasia in mice appears related to functional ties between several endocrines particularly adrenal, ovary, and pituitary. A study of the spontaneous benign and malignant tumors ocurring in control NEDH rats has provided background for the tumorigenic effects of radiation and also of altered hormonal internal milieu. Begin tumors have been produced by radiation in a wide variety of tissues for the first time, providing data as to the relative responsiveness in benign tumor production of various tissues to a dose of 1000 rads. The hormonal changes secondary to parabiosis and hemi-irradiation of the pair are important. A radiation-induced functioning pheochromocytoma causing hypertension and death has been found widely useful by investigators. A radiation-induced malignant insulinoma has also been widely used, and insulin-producing DNA from it has served in the hands of others through genetic engineering to provide an insulin-producing strain of the bacillus E. coli.
- Research Organization:
- New England Deaconess Hospital, Boston, MA (USA). Cancer Research Inst.
- OSTI ID:
- 6136440
- Report Number(s):
- COO-3017-39
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
ANIMALS
ASBESTOS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOMEDICAL RADIOGRAPHY
BODY
CARCINOGENESIS
CHRONIC EXPOSURE
CHRONIC IRRADIATION
DELAYED RADIATION EFFECTS
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
EXTERNAL IRRADIATION
FEMALES
GAMMA RADIATION
GLANDS
GONADOTROPINS
GONADS
HAZARDS
HEALTH HAZARDS
HORMONES
IONIZING RADIATIONS
IRRADIATION
LOCAL IRRADIATION
MALE GENITALS
MALES
MAMMALS
MAMMARY GLANDS
MAN
MEDICINE
MICE
MOSAICISM
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PANCREAS
PARABIOSIS
PATHOGENESIS
PEPTIDE HORMONES
PITUITARY HORMONES
PRIMATES
PROSTATE
RADIATION EFFECTS
RADIATION HAZARDS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RATS
RODENTS
SECRETION
SEX DEPENDENCE
TESTES
TRANSPLANTS
VERTEBRATES
WHOLE-BODY IRRADIATION
WOMEN
X RADIATION