Intestinal absorption and retention of cadmium in neonatal rat. [/sup 115m/Cd tracer technique]

Journal Article · Fri Dec 31 23:00:00 EST 1976 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(77)90043-6· OSTI ID:6468939

Sasser, L B; Jarboe, G E

Newborn rats were orally dosed at 2 or 24 hr of age with 1 ..mu..Ci of /sup 115m/Cd and killed at intervals between 1 and 21 days after dosing. Cadmium absorption (systemic absorption) was about six times greater in 2-hr-old pups as compared with 1-day-old pups, but the rate of absorption after Day 1 was similar in both age groups. Post weanling rats dosed at 6 weeks of age absorbed 0.5% of the Cd dose, whereas rats dosed at 2 and 24 hr of age absorbed approximately 12 and 5% of the dose, respectively. Cadmium was tenaciously retained in the gastrointestinal tract of newborn rats, with over 60% of the Cd dose remaining in the gastrointestinal tract 15 days after dosing. Autoradiographs showed considerable amounts of radioactivity not only in the intestinal surface epithelium and brush borders, but also in the crypts, lamina propia, and muscular layer. Because of the greater absorption and the prolonged intestinal retention of Cd in the newborn rat and the long biological half-life of Cd in the body, Cd exposure in infancy could result in greater lifetime Cd accumulation. The prolonged intestinal retention of Cd may have significant implications on the interpretation of short-term balance studies of metals.

• Research Organization: Comparative Animal Research Lab., Oak Ridge, TN
• OSTI ID: 6468939
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 41; ISSN TXAPA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CADMIUM
CADMIUM 115
CADMIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
ELEMENTS
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
ISOMERIC NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METALS
NEONATES
NUCLEI
RADIOISOTOPES
RATS
RETENTION
RODENTS
TRACER TECHNIQUES
UPTAKE
VERTEBRATES