Intestinal absorption and retention of cadmium in neonatal pigs compared to rats and guinea pigs
Journal Article
·
· J. Nutr.; (United States)
OSTI ID:6783792
The purpose of this study was to measure intestinal absorption and retention of cadmium in the newborn pig and to compare data from the pig, rat and guinea pig, three species that differ greatly in their ability to absorb macromolecules at birth. Newborn pigs were administered a single oral dose of 50 ..mu..Ci of /sup 115m/Cd 24 hours after birth and killed at intervals between 1 and 14 days after dosing. Cd absorption and gastrointestinal retention were then determined; these data were compared with similar data from the rat and guinea pig. Cd absorption in the neonate appears to be a two-step process; mucosal uptake of Cd from the lumen, probably by pinocytosis, followed by transfer of a portion of this Cd into the body. This transfer process is similar, but does not entirely coincide with changes associated with protein absorption in the neonate.
- Research Organization:
- Comparative Animal Research Lab., Oak Ridge, TN
- OSTI ID:
- 6783792
- Journal Information:
- J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 110:8; ISSN JONUA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CADMIUM
CADMIUM 115
CADMIUM ISOTOPES
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
ELEMENTS
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
GLANDS
GUINEA PIGS
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
INTESTINES
ISOMERIC NUCLEI
ISOTOPES
KIDNEYS
LARGE INTESTINE
LIVER
MAMMALS
METALS
NEONATES
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RETENTION
RODENTS
SMALL INTESTINE
STOMACH
SWINE
TIME DEPENDENCE
UPTAKE
VERTEBRATES
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CADMIUM
CADMIUM 115
CADMIUM ISOTOPES
CENTRAL NERVOUS SYSTEM
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DOMESTIC ANIMALS
ELEMENTS
EVEN-ODD NUCLEI
GASTROINTESTINAL TRACT
GLANDS
GUINEA PIGS
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
INTESTINES
ISOMERIC NUCLEI
ISOTOPES
KIDNEYS
LARGE INTESTINE
LIVER
MAMMALS
METALS
NEONATES
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RETENTION
RODENTS
SMALL INTESTINE
STOMACH
SWINE
TIME DEPENDENCE
UPTAKE
VERTEBRATES