Gastrointestinal absorption of /sup 95/Nb by rats of different ages

Journal Article · Tue Mar 01 04:00:00 EST 1977 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574668· OSTI ID:7106789

Mraz, F R; Eisele, G R

Carrier-free /sup 95/Nb in oxalic acid was administered via gavage to rats 6 hr, 7, 21, or 129 days of age, and these were sacrificed 4 days later. Rat pups less than 6 hr old were dosed in the above manner and sacrificed 1, 4, 5, 7, 9, 12, 15, 17, 19, or 21 days after dosing. After 4 days, significantly more /sup 95/Nb was found in the tissues and gastrointestinal tracts of the suckling pups than in those of the weanling or adult rats. Some of the /sup 95/Nb in the digestive tracts of the suckling pups must have been available for absorption since an elevation of /sup 95/Nb in the whole body was observed as late as 9 days after dosing when 20 percent of the dose was still in the gastrointestinal tract. The relatively high (6.6 percent of the dose) absorption of /sup 95/Nb by the suckling pup and the rather long residence time in the gastrointestinal tract would indicate that /sup 95/Nb would be more hazardous for the juvenile than for the adult.

• Research Organization: Comparative Animal Research Lab., Oak Ridge, TN
• OSTI ID: 7106789
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 69:3; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE DEPENDENCE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
GASTROINTESTINAL TRACT
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
METABOLISM
NIOBIUM 95
NIOBIUM ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
TISSUES
VERTEBRATES