Whole-body retention and intestinal absorption of /sup 115m/Cd in young and adult mice

Journal Article · Fri Dec 01 04:00:00 EST 1972 · Igaku To Seibutsugaku, v. 85, no. 6, pp. 275-279

OSTI ID:4403645

Matsusaka, N; Tanaka, M; Nishimura, Y; Yuyama, A; Kobayashi, H

A1 mu Ci/g body weight dose of /sup 115m/CdCl/sub 2/ in 150 mu Ci/ml of disti lled Water was given orally to young (7, 14, 21 days old) and adult mice, respectively. The retention rate of /sup 115m/CdCl/sub 2/ in each group of mice was counted by whole-body counter. The higher retention was observed in young mice. In the youngest group of mice (7 days old) in particular, the retention rate was comparatively high for the first 7 days after administration and decreased abruptly, which decreasing pattern was different from that in other groups. By counting the radioactivity in the extracted digestive tract of the youngest group of mice, it is estimated that about 66% of administered /sup 115m/ Cd was retained in the digestive tract and only 9% was retained in the other part of the body 24 hrs after administration. The retention rate of /sup 115m/Cd absorbed through the digestive tract 21 days after administration in the 7-, 14-, 21-day old mice and adult mice were 9, 8, 4, and 0.9% respectively of the total administered doses. In consecutive administration, absorption rate was also higher in the digestive tract of young mice. In each group, the excretion rate of /sup 115m/Cd was slight. (JA)

• Research Organization: Iwate Univ., Morioka, Japan
• NSA Number: NSA-29-010492
• OSTI ID: 4403645
• Journal Information: Igaku To Seibutsugaku, v. 85, no. 6, pp. 275-279, Journal Name: Igaku To Seibutsugaku, v. 85, no. 6, pp. 275-279; ISSN IGSBA
• Country of Publication: Japan
• Language: Japanese

Related Subjects

*CADMIUM 115-- RETENTION
*MICE-- RADIONUCLIDE KINETICS
AGE GROUPS
CADMIUM
EXCRETION
N48720* --Life Sciences--Nuclide Kinetics & Toxicology-- Animals
ORAL ADMINISTRATION
TRACER TECHNIQUES