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Identification of mutagens by frequency analysis of micronuclear normochromic erythrocytes

Journal Article · · Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
OSTI ID:6450102
; ; ;
Analysis of the frequency of polychromatophilic erythrocytes with micronuclei in mammalian bone marrow is a rapid and simple test used at the stage of detection of potential mutagens and carcinogens. Reports have recently been published that normochromic erythrocytes with micronuclei may accumulate in the peripheral blood of mice exposed repeatedly to chemical mutagens. The authors of these reports recommend that this modified micronuclear test be used for the intravital detection of mutagens. To assess the potential of this method for investigating the effects of mutagenic and carcinogenic pollutants occurring in drinking water, the authors of this paper compared the frequency of mature normochromic erythrocytes and young polychromatophilic erythrocytes with micronuclei in the peripheral blood as well as the frequency of chromosomal aberrations in the bone marrow cells of mice who were given cyclophosphamide, a model mutagen, with their drinking water.
Research Organization:
A.N. Sysin Research Institute of General and Community Hygiene, Moscow, USSR
OSTI ID:
6450102
Journal Information:
Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Journal Name: Bull. Exp. Biol. Med. (Engl. Transl.); (United States) Vol. 102:8; ISSN BEXBA
Country of Publication:
United States
Language:
English

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Related Subjects

550300 -- Cytology
550400 -- Genetics
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMAL CELLS
BIOASSAY
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BLOOD
BLOOD CELLS
BODY FLUIDS
BONE MARROW CELLS
CARCINOGENS
CELL CONSTITUENTS
CELL NUCLEI
CHROMOSOMAL ABERRATIONS
CHROMOSOMES
CHRONIC INTAKE
CONNECTIVE TISSUE CELLS
DETECTION
DOSE-RESPONSE RELATIONSHIPS
DRINKING WATER
DRUGS
ENDOXAN
ERYTHROCYTES
GENETIC EFFECTS
HAZARDS
HEALTH HAZARDS
HYDROGEN COMPOUNDS
IMMUNOSUPPRESSIVE DRUGS
INTAKE
MATERIALS
MUTAGENESIS
MUTAGENS
MUTATIONS
OXYGEN COMPOUNDS
POLLUTANTS
POLLUTION
SOMATIC CELLS
WATER
WATER POLLUTION