Cytogenetic analyses of mice exposed to dichloromethane
- National Institute of Environmental Health Sciences, Research Triangle Park, NC (USA)
Chromosome damage was studied in female B6C3F1 mice exposed to dichloromethane (DCM) by subcutaneous or inhalation treatments. No increase in the frequency of either sister chromatid exchanges (SCEs) or chromosome aberrations (CAs) in bone marrow cells was observed after a single subcutaneous injection of 2,500 or 5,000 mg/kg DCM. Inhalation exposure to DCM for 10 days at concentrations of 4,000 or 8,000 ppm resulted in significant increases in frequencies of SCEs in lung cells and peripheral blood lymphocytes, CAs in lung and bone marrow cells, and micronuclei (MN) in peripheral blood erythrocytes. Lung cell CAs and blood erythrocyte MN reached frequencies of approximately two times control levels. Following a 3-month inhalation exposure to 2,000 ppm DCM, mice showed small but significant increases in lung cell SCEs and peripheral blood erythrocyte MN. These findings suggest that genotoxicity may play a role in the carcinogenicity of DCM in the lungs of B6C3F1 female mice.
- OSTI ID:
- 5848342
- Journal Information:
- Environmental and Molecular Mutagenesis; (USA), Journal Name: Environmental and Molecular Mutagenesis; (USA) Vol. 15:4; ISSN EMMUE; ISSN 0893-6692
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW CELLS
CARCINOGENESIS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
ERYTHROCYTES
GENETIC EFFECTS
INHALATION
INTAKE
LUNGS
MAMMALS
MATERIALS
METHYLENE CHLORIDE
MICE
MUTATION FREQUENCY
MUTATIONS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PATHOGENESIS
RESPIRATORY SYSTEM
RESPIRATORY TRACT CELLS
RODENTS
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
VERTEBRATES