The Dependence of the Mutagenic Effect on the Dose of X-Ray Irradiation in an In Vivo Experiment on Female (CBA×C57Bl/6)F1 Mice

Journal Article · Thu Nov 15 04:00:00 EST 2018 · Bulletin of Experimental Biology and Medicine

DOI:https://doi.org/10.1007/S10517-018-4285-5· OSTI ID:22927948

Shchegoleva, R. A.; Lisina, N. I.; Gordeev, A. V.; Rozhdestvenskii, L. M. ^[1]

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1. A. I. Burnazyan Federal Medical Biophisical Center, Federal Medical and Biological Agency of the Moscow (Russian Federation)

We studied the mutagenic effect of X-ray irradiation in doses of 0.5, 1, and 1.5 Gy on female (CBA×C57Bl/6)F1 mice. The mutagenic effect (assessed by the parameter “frequency of bone marrow polychromatophilic erythrocytes with micronuclei”) linearly depended on the dose of X-ray irradiation in the range of up to 1 Gy and reached the plateau at 1.5 Gy. The fraction of polychromatophilic erythrocytes was 45, 45, and 46% under control conditions (without exposure) and exposure to the irradiation in the doses of 0.5 and 1 Gy, respectively. Irradiation in a dose of 1.5 Gy induced a slight inhibition of erythropoiesis. These data confirm the hypothesis on possible death of highly aberrant erythrocyte precursors after irradiation in high doses.

• OSTI ID: 22927948
• Journal Information: Bulletin of Experimental Biology and Medicine, Journal Name: Bulletin of Experimental Biology and Medicine Journal Issue: 1 Vol. 166; ISSN BEXBAN; ISSN 0007-4888
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BONE MARROW
ERYTHROCYTES
ERYTHROPOIESIS
IN VIVO
IRRADIATION
MICE
RADIATION DOSES
X RADIATION