Chronic air-flow limitation does not increase respiratory epithelial permeability assessed by aerosolized solute, but smoking does
To determine the separate influences of smoking and severe air-flow limitation on aerosol deposition and respiratory epithelial permeability, we studied 26 normal nonsmokers, 12 smokers without airway obstruction, 12 nonsmokers with chronic obstructive pulmonary disease (COPD), and 11 smokers with COPD. We aerosolized 99mTc-labeled diethylene triamine pentaacetic acid to particles approximately 1 micron activity median aerodynamic diameter. Levels of radioactivity were plotted semilogarithmically against time to calculate clearance as percent per minute. The distribution of radioactivity was homogeneous in control subjects and in smokers, but patchy in both groups with COPD. No difference was found between clearances of the control group (1.18 +/- 0.31% min-1), and nonsmoker COPD group (1.37 +/- 0.82% min-1), whereas values in smokers without COPD (4.00 +/- 1.70% min-1) and smokers with COPD (3.62 +/- 2.88% min-1) were significantly greater than in both nonsmoking groups. We conclude that (1) small particles appear to deposit peripherally, even with severe COPD; (2) respiratory epithelial permeability is normal in nonsmokers with COPD; (3) smoking increases permeability by a mechanism unrelated to air-flow limitation.
- Research Organization:
- Clinique de Pneumophthisiologie and INSERM U 214, Hopital Laennec, Paris, France
- OSTI ID:
- 6442835
- Journal Information:
- Am. Rev. Respir. Dis.; (United States), Vol. 130:3
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
DTPA
LUNG CLEARANCE
TOBACCO SMOKES
HEALTH HAZARDS
INHALATION
ISOMERIC NUCLEI
LABELLED COMPOUNDS
MAN
PARTICULATES
RESPIRATORY SYSTEM DISEASES
TECHNETIUM 99
TRACER TECHNIQUES
AEROSOLS
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
DISEASES
DISPERSIONS
DRUGS
EXCRETION
HAZARDS
HOURS LIVING RADIOISOTOPES
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PARTICLES
PRIMATES
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESIDUES
SMOKES
SOLS
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)
551001 - Physiological Systems- Tracer Techniques