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Rapidly reversible alterations of pulmonary epithelial permeability induced by smoking

Journal Article · · Chest; (United States)
DOI:https://doi.org/10.1378/chest.83.1.6· OSTI ID:5986997
; ; ;

A radioaerosol procedure using /sup 99m/Tc-DTPA (diethylene triamine penta acetate) was used to evaluate the permeability of the pulmonary epithelium in smokers and nonsmokers. The average clearance of this indicator from the lungs of smokers without significant airway obstruction exceeded that found in normal subjects by an average factor of more than five. This abnormality was observed throughout all lung regions. /sup 99m/Tc-DTPA clearance decreased rapidly during the week after smoking was discontinued. It is concluded that smoking results in a rapidly reversible increase in pulmonary epithelial permeability.

Research Organization:
Division of Respiratory Physiology, Harbor-UCLA Medical Center, Torrance
OSTI ID:
5986997
Journal Information:
Chest; (United States), Journal Name: Chest; (United States) Vol. 83:1; ISSN CHETB
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560306 -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
DIAGNOSTIC USES
DISPERSIONS
DRUGS
DTPA
EPITHELIUM
EXCRETION
HAZARDS
HEALTH HAZARDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNG CLEARANCE
LUNGS
MAMMALS
MAN
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGY
PERMEABILITY
PRIMATES
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESIDUES
RESPIRATORY SYSTEM
SMOKES
SOLS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
TOBACCO SMOKES
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES