Regional respiratory clearance of aerosolized /sup 99m/Tc-DTPA: posture and smoking effects

Journal Article · Sun Jun 01 04:00:00 EDT 1986 · J. Appl. Physiol.; (United States)

OSTI ID:5004831

Dusser, D J; Minty, B D; Collignon, M A; Hinge, D; Barritault, L G; Huchon, G J

We studied 10 healthy nonsmokers and 8 healthy smokers, in both the upright and supine position, to investigate whether regional differences in respiratory clearance of technetium-99m-labeled diethylenetriamine pentaacetic acid /sup 99m/Tc-DTPA (RC-DTPA) existed and to assess the influence of posture and smoking on the regional RC-DTPA. RC-DTPA was assessed by the lung clearance rates (%/min) of aerosolized /sup 99m/Tc-DTPA (0.8 micron MMD; 2.4 GSD), using data corrected for recirculating radioactivity, in the upper (zone 1), middle (zone 2), and lower (zone 3) posterior lung fields. In nonsmokers, RC-DTPA in zone 1 was faster than in zone 2 or 3 in both the upright (P less than 0.001) and supine positions (P less than 0.0). No effect was produced by changes in posture on the regional RC-DTPA. In smokers, RC-DTPA was increased in all zones compared with the nonsmokers (P = 0.004), with a further increase in RC-DTP in zone 1 in the upright posture compared with the other regions (P less than 0.001). We conclude that in nonsmokers regional RC-DTPA is faster in zone 1 than in other zones, and this is not related to recirculation of radioactivity; posture does not modify the regional RC-DTPA of nonsmokers; smoking increases RC-DTPA in all zones and more in zone 1 in the upright posture.

• OSTI ID: 5004831
• Journal Information: J. Appl. Physiol.; (United States), Journal Name: J. Appl. Physiol.; (United States) Vol. 6; ISSN JAPYA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AEROSOLS
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
DISPERSIONS
DISTRIBUTION
DRUGS
DTPA
EXCRETION
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNG CLEARANCE
MAMMALS
MAN
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
POSITIONING
PRIMATES
RADIOACTIVE AEROSOLS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESIDUES
RESPIRATORY SYSTEM
SMOKES
SOLS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
TOBACCO SMOKES
VERTEBRATES
YEARS LIVING RADIOISOTOPES