Comparison of lung vascular and epithelial permeability indices in the adult respiratory distress syndrome

Journal Article · Sun Jun 01 04:00:00 EDT 1986 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:5206263

Braude, S; Nolop, K B; Hughes, J M; Barnes, P J; Royston, D

Measurements of pulmonary clearance of inhaled /sup 99m/Tc-DTPA and transvascular 113mIn-transferrin flux were made in 12 patients with established ARDS and 14 volunteer control subjects (7 smokers and 7 nonsmokers). Smokers had significantly increased /sup 99m/Tc-DTPA clearance (clearance rate constant, 3.6 +/- 0.8; mean +/- SEM) compared with nonsmokers (1.2 +/- 0.1). All patients with ARDS had increased clearance of /sup 99m/Tc-DTPA (5.2 +/- 0.9), but the finding was nonspecific in that increased clearance overlapped with the findings in normal smokers. Protein flux in smokers (protein flux units, 0.0 +/- 0.2) was similar to that in nonsmokers (0.3 +/- 0.2). In 9 of the 12 patients with ARDS, protein flux was increased, and as a group (3.2 +/- 1.0) they differed significantly (p less than 0.01) from the combined smoking and nonsmoking control subjects (0.2 +/- 0.1, n = 14). The parameters of DTPA clearance and transvascular protein flux correlated well in the patients with ARDS (Spearman's rank correlation = 0.71, p less than 0.01). Although /sup 99m/Tc-DTPA clearance is a sensitive technique in ARDS, a single study in this context does not allow a diagnostic conclusion because of its non-specificity. Abnormal protein flux appears to be more specific for ARDS but was not a universal finding in the patients studied.

• Research Organization: Royal Postgraduate Medical School, London, England
• OSTI ID: 5206263
• Journal Information: Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 6; ISSN ARDSB
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHELATING AGENTS
CLEARANCE
DISEASES
DRUGS
DTPA
EPITHELIUM
GLOBULINS
GLOBULINS-BETA
HOURS LIVING RADIOISOTOPES
INDIUM 113
INDIUM ISOTOPES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNGS
MEMBRANE TRANSPORT
METALLOPROTEINS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PERMEABILITY
PROTEINS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
STABLE ISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
TRANSFERRIN
YEARS LIVING RADIOISOTOPES