Asbestosis. Bronchoalveolar lavage fluid proteins and their relationship to pulmonary epithelial permeability

Journal Article · Fri Nov 01 04:00:00 EST 1985 · Chest; (United States)

OSTI ID:6252680

Gellert, A R; Perry, D; Langford, J A; Riches, P G; Rudd, R M

The authors measured levels of albumin and immunoglobulins in serum and bronchoalveolar lavage (BAL) fluid in 28 men with asbestosis and 11 control subjects. The half-time clearance of inhaled diethylene triamine pentacetate labelled with technetium-99m (/sup 99m/Tc-DTPA) from the lungs (t1/2LB) was measured in 26 patients with asbestosis and in 31 normal nonsmoking controls. In those individuals in whom immunoglobulins were detected in BAL fluid, the mean IgG:albumin ratio in BAL fluid was 0.30, significantly less than the ratio of 0.43 in control subjects. There was no significant difference in IgA:albumin ratios between patients and control subjects. The mean BAL:serum albumin ratio in patients with asbestosis was 2.3 X 10(-3). The t1/2LB was significantly shorter in both smokers and nonsmokers with asbestosis, compared with 31 normal nonsmoking controls, but there were no relationships between t1/2LB and BAL:serum albumin ratio or any other BAL protein levels in either smokers or nonsmokers with asbestosis.

• Research Organization: London Chest Hospital, England
• OSTI ID: 6252680
• Journal Information: Chest; (United States), Journal Name: Chest; (United States) Vol. 5; ISSN CHETB
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
ASBESTOS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMISTRY
BODY
CARBOXYLIC ACIDS
CHELATING AGENTS
CHEMISTRY
CLEARANCE
DIAGNOSIS
DISEASES
DRUGS
DTPA
EPITHELIUM
EXCRETION
GLOBULINS
HOURS LIVING RADIOISOTOPES
IMMUNOGLOBULINS
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LAVAGE
LUNG CLEARANCE
MALES
MAMMALS
MAN
MEN
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PERMEABILITY
PRIMATES
PROTEINS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM DISEASES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES