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Lymphocyte subpopulations in bronchoalveolar lavage fluid in asbestos workers

Journal Article · · Am. Rev. Respir. Dis.; (United States)
OSTI ID:6177545
; ; ; ;
The authors examined peripheral blood and bronchoalveolar lavage (BAL) fluid lymphocyte subpopulations in 29 asbestos workers, 10 with and 19 without clinical or radiologic evidence of asbestosis. Peripheral blood lymphocyte subpopulations were also measured in 13 control subjects. The mean OKT4:OKT8 (T-helper/inducer:T-suppressor/cytotoxic lymphocyte) ratio in BAL fluid in the 29 asbestos workers was 0.96, significantly less than 1.76 in peripheral blood. There were no significant differences in OKT4:OKT8 ratios in peripheral blood between the 10 patients with asbestosis, the 19 asbestos workers without asbestosis, and the 13 normal control subjects or in the OKT4:OKT8 ratios in BAL fluid between patients with asbestosis and asbestos workers without asbestosis. In the group as a whole, 83% of those who had suffered more than 5 yr of exposure to asbestos showed OKT4:OKT8 ratios less than 1.2, whereas in those who had suffered fewer than 5 yr of exposure, 80% showed ratios greater than 1.2. No other relationships between OKT4:OKT8 ratios and clinical, radiographic, or physiologic variables were observed.
Research Organization:
London Chest Hospital, England
OSTI ID:
6177545
Journal Information:
Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 4; ISSN ARRDA
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ASBESTOS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COUNT
BODY
BODY FLUIDS
BRONCHI
CONNECTIVE TISSUE CELLS
DISEASES
IRRIGATION
LAVAGE
LEUKOCYTES
LUNGS
LYMPHOCYTES
MATERIALS
OCCUPATIONAL EXPOSURE
ORGANS
PERSONNEL
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SOMATIC CELLS