Effects of common therapeutic concentrations of oxygen on lung clearance of /sup 99m/Tc DTPA and bronchoalveolar lavage albumin concentration

Journal Article · Fri Aug 01 04:00:00 EDT 1986 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:5121784

Griffith, D E; Holden, W E; Morris, J F; Min, L K; Krishnamurthy, G T

We studied the effects of oxygen concentrations (21 to 50%) considered clinically safe on clearance of inhaled technetium-labeled diethylene triamine pentaacetate (/sup 99m/Tc DTPA) and the concentration of albumin in bronchoalveolar lavage (BAL) fluid of normal subjects. We also measured several markers of cell injury and inflammation in the BAL fluid including total and differential cell counts, lactate dehydrogenase, alkaline phosphatase, extracellular potassium, and several eicosanoids. Subjects inhaled oxygen (50, 40, 30, or 21%) for a mean of 45 h; there were no symptoms or bronchoscopic signs of oxygen toxicity. The concentration of albumin in BAL fluid was increased compared with baseline measurements in a dose-dependent manner in subjects exposed to 30% oxygen and above. Clearance of /sup 99m/Tc DTPA was increased only in subjects who inhaled 50% oxygen. There were no significant changes in BAL fluid volume or total and differential cell counts after oxygen exposure. A trend towards an increased percentage of polymorphonuclear leukocytes was noted in the 50% oxygen group. We found no evidence of cell injury or inflammation in the BAL fluid. Supplemental humidity did not appear to influence the findings in the 50% oxygen group. Thus, oxygen in concentrations considered clinically safe increases clearance of /sup 99m/Tc DTPA and BAL albumin concentration in normal subjects after a relatively short time of exposure.

• Research Organization: Veterans Hospital Medical Center, Portland, OR
• OSTI ID: 5121784
• Journal Information: Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 2; ISSN ARDSB
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALBUMINS
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
DRUGS
DTPA
ELEMENTS
EXCRETION
HOURS LIVING RADIOISOTOPES
HUMIDITY
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LUNG CLEARANCE
MAMMALS
MAN
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXYGEN
PRIMATES
PROTEINS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES