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Bronchoalveolar lavage in ponies with recurrent airway obstruction (heaves)

Journal Article · · Am. Rev. Respir. Dis.; (United States)
OSTI ID:6133113
; ; ; ;
The authors performed bronchoalveolar lavage (BAL) in 2 groups of ponies. Principal ponies had a history of heaves, a disease characterized by recurrent airway obstruction and airway hyperreactivity when ponies are housed in a barn and fed hay; control ponies had no history of airway obstruction. Ponies were paired (principal and control), and BAL was performed after 2 months of being pastured when principal ponies were in clinical remission (Period A), after barn housing when principal ponies had acute airway obstruction (Period B), and after a 1- and a 2-wk recovery phase of pasture grazing (Periods C and D). At Periods A, C, and D, white blood cell counts and immunoglobulin/albumin ratios in peripheral blood and BAL fluid of principal and control animals did not differ. However, at Period B, neutrophil numbers in the BAL fluid were increased in the principal but not in the control animals. The IgG/albumin ratio of the principal animals increased at Period C. They conclude that in ponies with a history of heaves, barn exposure results in increased neutrophils in BAL fluid. In this pony model of lung disease, pulmonary leukostasis follows a time course similar to that of airway obstruction and airway hyperreactivity.
Research Organization:
Michigan State Univ., East Lansing
OSTI ID:
6133113
Journal Information:
Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 5; ISSN ARRDA
Country of Publication:
United States
Language:
English

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Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ALBUMINS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD COUNT
BODY FLUIDS
BRONCHI
DISEASES
DUSTS
GLOBULINS
HORSES
IMMUNOGLOBULINS
INDOOR AIR POLLUTION
LAVAGE
LEUKOCYTES
MAMMALS
MATERIALS
NEUTROPHILS
ORGANIC COMPOUNDS
OZONE
POLLUTION
PROTEINS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
VERTEBRATES