Biomarkers of inflammation in ozone-exposed humans: Comparison of the nasal and bronchoalveolar lavage
Technical Report
·
OSTI ID:6005416
An influx of neutrophils (PMNs), a primary feature of acute inflammation, has been associated with the development of lower lung disorders, such as emphysema and idiopathic fibrosis, as well as airway hyperreactivity and increased mucus secretion. It was previously established that an acute inflammatory response in the upper respiratory tract of humans could be studied by analysis of nasal lavages (NL), which is inexpensive, non-invasive, and atraumatic. However, the relationship of the cellular changes in the upper respiratory tract to changes in the lower airways has not been thoroughly investigated in humans. Here the cellular changes detected in the NL with those detected in the bronchoalveolar lavage (BAL) taken from the same individual have been compared. Ten subjects were exposed to either filtered air or 0.4 ppm ozone (O3), with exercise, for 2 hrs. The NL was done prior to, immediately following an 18 hr post exposure, while the BAL was done only at 18 hr post exposure. A significant increase in PMNs was detected in the NL immediately post exposure to 03, (7.7-fold increase; p=.003), and remained elevated in the 18 hr post-03 NL (6.1-fold increase; p<.001).
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 6005416
- Report Number(s):
- PB-91-145060/XAB; EPA--600/J-90/280
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
BIOLOGICAL MARKERS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
EXERCISE
FIBROSIS
INFLAMMATION
LAVAGE
LEUKOCYTES
LUNGS
MAMMALS
MAN
MATERIALS
NEUTROPHILS
ORGANS
OZONE
PATHOLOGICAL CHANGES
POLLUTION
PRIMATES
RESPIRATORY SYSTEM
SENSITIVITY
SYMPTOMS
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
BIOLOGICAL MARKERS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
EXERCISE
FIBROSIS
INFLAMMATION
LAVAGE
LEUKOCYTES
LUNGS
MAMMALS
MAN
MATERIALS
NEUTROPHILS
ORGANS
OZONE
PATHOLOGICAL CHANGES
POLLUTION
PRIMATES
RESPIRATORY SYSTEM
SENSITIVITY
SYMPTOMS
TOXICITY
VERTEBRATES