Lung inflammation in coal miners assessed by uptake of 67Ga-citrate and clearance of inhaled 99mTc-labeled diethylenetriamine pentaacetate aerosol

Journal Article · Wed Jul 01 00:00:00 EDT 1992 · American Review of Respiratory Disease (New York); (United States)

DOI:https://doi.org/10.1164/ajrccm/146.1.47· OSTI ID:7042697

Susskind, H; Rom, W N ^[1]

---

1. Clinical Research Center, Brookhaven National Laboratory, Upton, NY (United States)

The authors compared the diffuse lung uptake of 67Ga-citrate, an index of inflammatory lung activity, with the lung clearance of inhaled 99mTc-labeled diethylenetriamine pentaacetate (DTPA) aerosol, an index of pulmonary epithelial permeability, in a group of 19 West Virginia coal miners whose pulmonary status was compatible with coal worker's pneumoconiosis. 99mTc-DTPA clearance alone and 67Ga-citrate uptake alone were measured in nine and five additional subjects, respectively. The objective of this study was to determine if increased 99mTc-DTPA lung clearance was caused by inflammation at the lung epithelial surfaces. Subjects inhaled approximately 150 microCi (approximately 5.6 MBq) of 99mTc-DTPA aerosol, and quantitative gamma camera images of the lungs were acquired at 1-min increments for 25 min. Regions of interest (ROI) were selected to include (1) both lungs; (2) each individual lung; and (3) the upper, middle, and lower thirds of each lung. 99mTc-DTPA clearance was determined from the slopes of the respective time-activity plots for the different ROI. Each subject was intravenously administered 50 miCroCk (1.9 MBq)/kg 67Ga-citrate 48 to 72 h before imaging the body between neck and pelvis. The extent of 67Ga-citrate lung uptake was expressed as the gallium index (GI). Mean radioaerosol clearance half-time (T1/2) for the six nonsmoking coal miners (60.6 +/- 16.0 min) was significantly shorter (p less than 0.001) than for the nonsmoking control group (123.8 +/- 28.7 min). T1/2 for the 12 smoking miners (18.4 +/- 10.2 min) was shorter than for the smoking control group (33.1 +/- 17.8 min), but the difference did not attain statistical significance.

• OSTI ID: 7042697
• Journal Information: American Review of Respiratory Disease (New York); (United States), Journal Name: American Review of Respiratory Disease (New York); (United States) Vol. 146:1; ISSN ARDSB; ISSN 0003-0805
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
016000* -- Coal
Lignite
& Peat-- Health & Safety
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560300 -- Chemicals Metabolism & Toxicology
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CHELATING AGENTS
CITRATES
CLEARANCE
COAL MINERS
COAL MINING
COLLOIDS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DISPERSIONS
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
EPITHELIUM
EXCRETION
GALLIUM 67
GALLIUM ISOTOPES
HAZARDS
HEALTH HAZARDS
HOURS LIVING RADIOISOTOPES
IMAGE PROCESSING
INFLAMMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNG CLEARANCE
LUNGS
MAMMALS
MAN
MINERS
MINING
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PERMEABILITY
PERSONNEL
PNEUMOCONIOSES
PRIMATES
PROCESSING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESIDUES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SMOKES
SOLS
SYMPTOMS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
TOBACCO SMOKES
VERTEBRATES
YEARS LIVING RADIOI