Radioaerosol clearance to monitor effects of ozone on lung permeability

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6698207

Webb, D A; Utell, M J; Bauer, M A; Banko, T M; Waldman, D L; Morrow, P E; Hyde, R W

The Tc-99m DTPA aerosol clearance procedure was used to investigate the effects of low level ozone inhalation on lung permeability. Total and regional lung clearance was determined by scintillation camera imaging of 15 adult subjects presenting no history of lung disease using a radioaerosol with an aerodynamic diameter 0.5 ..mu..m(sigmag=1.50). Pulmonary function measurements and the radioaerosol procedure were conducted in each patient on at least two separate occasions. FVC, FEVl and airway resistance was measured pre and post monitored breathing of room air (30 min) and a subsequent aerosol clearance procedure was conducted as a baseline study; the same procedures were repeated after three or more days with 0.5 ppm ozone substituted for room air. The major observations from the clearance studies and the pulmonary function tests include: 1) no significant changes were detected between the baseline and ozone pulmonary function tests, 2) ROI analyses of the 30 min clearance data show no significant changes in the average Tc-99m DTPA clearance between the baseline room air (t1/2=85+-30 min) and ozone (t1/2=83+-24min) inhalation studies, and, 3) despite consistent average clearance rates, 7/15 subjects showed large changes in clearance (..delta..=24-72 min) and functional mapping showed major shifts in distribution in 5/15 subjects after ozone inhalation. The apparent high sensitivity, yet somewhat disparate observations, support the need of further investigation of factors influencing radioaerosol for the study of lung epithelial permeability.

• Research Organization: Univ. of Rochester School of Medicine and Dentistry, Rochester, NY
• OSTI ID: 6698207
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560300* -- Chemicals Metabolism & Toxicology
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADULTS
AEROSOLS
AGE GROUPS
AIR POLLUTION MONITORING
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CAMERAS
CARBOXYLIC ACIDS
CHELATING AGENTS
CLEARANCE
COLLOIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DISPERSIONS
DRUGS
DTPA
DYNAMIC FUNCTION STUDIES
EXCRETION
FLOW RATE
HOURS LIVING RADIOISOTOPES
IMAGE SCANNERS
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LUNG CLEARANCE
LUNGS
MEASURING METHODS
MONITORING
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OZONE
PATIENTS
PERMEABILITY
RADIOACTIVE AEROSOLS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SCINTISCANNING
SENSITIVITY
SOLS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TIME DEPENDENCE
YEARS LIVING RADIOISOTOPES