Chemical breakdown of radioaerosols during nebulization
The diagnostic utility of radioaerosols for lung ventilation and lung permeability procedures requires a strong, stable coordinate covalent bond between a radionuclide and a ligand. The stability of the radiopharmaceutical before and after nebulization and hence its molecular size, are an absolute prerequisite for the method to be reproducible. To examine the possible effects of aerosolization on radiopharmaceuticals used for pulmonary imaging, the authors examined the radiochemical purity of Tc-99m DTPA following ultrasonic nebulization, jet nebulization (Dautrebande D-31), and inhalation with subsequent appearance in plasma and urine of dogs. Paper and liquid chromatographic methods were applied to determine radiochemical purity. Chromatographic assays showed a binding efficiency of less than 50% for ultrasonicly aerosolized Tc-99m DTPA. Cooling of the ultrasonic coupling fluid increased the binding efficiency to greater than 95% following nebulization and inhalation. Jet nebulization did not affect the radiochemical purity of the radiopharmaceutical. Ultrasonic nebulization will partially destroy the Tc-99m DTPA complex; cooling the ultrasonic connecting fluid and constant aerosol monitoring are required for consistent, reproducible results.
- Research Organization:
- Univ. of Rochester School of Medicine and Dentistry, Rochester, NY
- OSTI ID:
- 6854854
- Report Number(s):
- CONF-850611-; TRN: 87-010764
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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LUNGS
PERMEABILITY
RADIOISOTOPE SCANNING
ULTRASONOGRAPHY
TECHNETIUM 99
DIAGNOSTIC USES
BINDING ENERGY
BLOOD PLASMA
CHEMICAL BONDS
CHROMATOGRAPHY
COMPARATIVE EVALUATIONS
DIAGNOSIS
DOGS
INHALATION
LIGANDS
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BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
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HOURS LIVING RADIOISOTOPES
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
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MAMMALS
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TECHNETIUM ISOTOPES
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VERTEBRATES
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550601* - Medicine- Unsealed Radionuclides in Diagnostics
550602 - Medicine- External Radiation in Diagnostics- (1980-)