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Chemical breakdown of radioaerosols during nebulization

Conference · · J. Nucl. Med.; (United States)
OSTI ID:6854854
; ; ; ; ; ;

The diagnostic utility of radioaerosols for lung ventilation and lung permeability procedures requires a strong, stable coordinate covalent bond between a radionuclide and a ligand. The stability of the radiopharmaceutical before and after nebulization and hence its molecular size, are an absolute prerequisite for the method to be reproducible. To examine the possible effects of aerosolization on radiopharmaceuticals used for pulmonary imaging, the authors examined the radiochemical purity of Tc-99m DTPA following ultrasonic nebulization, jet nebulization (Dautrebande D-31), and inhalation with subsequent appearance in plasma and urine of dogs. Paper and liquid chromatographic methods were applied to determine radiochemical purity. Chromatographic assays showed a binding efficiency of less than 50% for ultrasonicly aerosolized Tc-99m DTPA. Cooling of the ultrasonic coupling fluid increased the binding efficiency to greater than 95% following nebulization and inhalation. Jet nebulization did not affect the radiochemical purity of the radiopharmaceutical. Ultrasonic nebulization will partially destroy the Tc-99m DTPA complex; cooling the ultrasonic connecting fluid and constant aerosol monitoring are required for consistent, reproducible results.

Research Organization:
Univ. of Rochester School of Medicine and Dentistry, Rochester, NY
OSTI ID:
6854854
Report Number(s):
CONF-850611-
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:5; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AEROSOLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BINDING ENERGY
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BLOOD PLASMA
BODY
BODY FLUIDS
CHEMICAL BONDS
CHEMISTRY
CHROMATOGRAPHY
COLLOIDS
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC USES
DISPERSIONS
DOGS
DRUGS
ENERGY
HOURS LIVING RADIOISOTOPES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGANDS
LUNGS
MAMMALS
MATERIALS
MONITORING
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PERMEABILITY
PURIFICATION
RADIOACTIVE AEROSOLS
RADIOCHEMISTRY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RESPIRATORY SYSTEM
SEPARATION PROCESSES
SOLS
STABILITY
TECHNETIUM 99
TECHNETIUM ISOTOPES
ULTRASONOGRAPHY
URINE
USES
VENTILATION
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES