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Tc-99m radioaerosol clearance as an index of pulmonary epithelial permeability

Thesis/Dissertation ·
OSTI ID:5186403

This investigation examines radiopharmaceutical clearance as an index of alveolar-capillary membrane permeability and as an indicator of disease. Specific objectives include: evaluation of radiopharmaceutical chemical purity following aerosolization, investigation of a chemically related family of compounds to develop new radiopharmaceuticals with improved chemical properties, determination of reproducibility of the radiopharmaceutical clearance technique and the evaluation of the sensitivity of aerosolized solute clearance as an indicator of lung injury. The integrity of the radiopharmaceutical was examined prior to and following aerosol generation. The in vivo pharmacokinetics of a family of aerosolized solutes was evaluated in the beagle dog. The reproducibility of the biological response to radiopharmaceutical deposition was evaluated using dynamic functional imaging in humans and in the beagle. The sensitivity of the technique was evaluated using Tc-99m DTPA and an animal model for lung injury.

Research Organization:
Rochester Univ., NY (USA)
OSTI ID:
5186403
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANIMAL TISSUES
ANIMALS
BEAGLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BODY
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CELL MEMBRANES
CHELATING AGENTS
CHEMICAL PROPERTIES
CLEARANCE
DIAGNOSIS
DISEASES
DOGS
DRUGS
DTPA
EPITHELIUM
EXCRETION
HOURS LIVING RADIOISOTOPES
IMAGE PROCESSING
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LUNG CLEARANCE
LUNGS
MAMMALS
MAN
MEMBRANES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PERMEABILITY
PRIMATES
PROCESSING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SENSITIVITY ANALYSIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES