In vivo and in vitro radiosensitivities ofnewly established mouse ascites tumors
Journal Article
·
· Radiat. Res.; (United States)
- Univ. of Environmental and Occupational Health, Yahatanishi, Japan
The response of two newly established mouse mammary tumors to x irradiation in vitro and in vivo was studied by colony-forming assay in soft agar. Cells irradiated in vivo were more resistant than those irradiated in vitro. The D/sub 0/ values for in vitro irradiation were 112 rad at both exponential and stationary phases, while those for in vivo irradiation were 303 rad at exponential phase and 556 rad at stationary phase. This increase in D/sub 0/ value, which is greater than the OER, suggests that radiosensitivity in vivo cannot be explained only by hypoxia.
- OSTI ID:
- 6442742
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 85:3; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
ASCITES TUMOR CELLS
BIOASSAY
BODY
COLONY FORMATION
COMPARATIVE EVALUATIONS
DOSES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
GLANDS
IN VITRO
IN VIVO
IONIZING RADIATIONS
MAMMALS
MAMMARY GLANDS
MICE
ORGANS
RADIATION DOSES
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
TUMOR CELLS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANOXIA
ASCITES TUMOR CELLS
BIOASSAY
BODY
COLONY FORMATION
COMPARATIVE EVALUATIONS
DOSES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
GLANDS
IN VITRO
IN VIVO
IONIZING RADIATIONS
MAMMALS
MAMMARY GLANDS
MICE
ORGANS
RADIATION DOSES
RADIATIONS
RADIOSENSITIVITY
RADIOSENSITIVITY EFFECTS
RESPONSE MODIFYING FACTORS
RODENTS
TUMOR CELLS
VERTEBRATES
X RADIATION