Radiosensitivity of progenitor cells of the hematopoietic microenvironment. [Comparison in vitro and in vivo]
Journal Article
·
· Radiat. Res.; (United States)
The radiosensitivity of cells which transfer hematopoietic microenvironment was studied in a model in which femoral bone marrow is transplanted under the renal capsule of a mouse. For in vitro /sup 137/Cs ..gamma.. irradiation, the D/sub o/ for the hamatopoietic microenvvironment transferring units (HMTU) was 444 +- 5 rad and the extrapolation number (n) was 5.2. The value of the quasi-threshold dose (D/sub q/) was approximately 500 rad which reflects the high capacity of HMTU for repair of sublethal injury. After in vivo exposure to ..gamma.. rays, HMTU radiosensitivity was somewhat higher (D/sub o/ of 325 +- 25 rad, n of 3.5, and D/sub q/ of 635 rad). For in vitro irradiation with fast neutrons, the D/sub o/ was 161 +- 19 rad and n, 1.4. On the basis of the fraction of transplant failures after exposure to different radiation doses it was calculated that one femoral marrow plug contains about 50 HMTU.
- Research Organization:
- Central Inst. of Hematology and Blood Transfusion, Moscow, USSR
- OSTI ID:
- 5685949
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 19:1; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BONE MARROW CELLS
CELL CULTURES
CESIUM 137
CESIUM ISOTOPES
CFU
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
FAST NEUTRONS
FERMIONS
GAMMA RADIATION
HADRONS
IN VITRO
IN VIVO
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOTOPES
MAMMALS
MICE
NEUTRONS
NUCLEI
NUCLEONS
NUMERICAL DATA
ODD-EVEN NUCLEI
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
STEM CELLS
TRANSPLANTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BONE MARROW CELLS
CELL CULTURES
CESIUM 137
CESIUM ISOTOPES
CFU
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
FAST NEUTRONS
FERMIONS
GAMMA RADIATION
HADRONS
IN VITRO
IN VIVO
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
ISOTOPES
MAMMALS
MICE
NEUTRONS
NUCLEI
NUCLEONS
NUMERICAL DATA
ODD-EVEN NUCLEI
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY
RODENTS
SOMATIC CELLS
STEM CELLS
TRANSPLANTS
VERTEBRATES
YEARS LIVING RADIOISOTOPES