Radiosensitivity of pulmonary alveolar macrophage colony-forming cells

Journal Article · Mon Feb 01 04:00:00 EST 1982 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575774· OSTI ID:5654608

Lin, H S; Kuhn, C; Chen, D M

The proliferative state and the radiosensitivity of pulmonary alveolar macrophage colony-forming cells were investigated. The fraction of colony-forming cells in S phase was determined by exposing these cells in vitro to (/sup 3/H)thymidine with a high specific activity. No appreciable reduction in the number of colony-forming cells was found. It is concluded from these data that only a very small fraction of them are in active cell cycle or they proliferate very slowly, if at all, in vitro. These colony-forming cells were more resistant to ..gamma.. irradiation than peritoneal exudate macrophage colony-forming cells. The values of D/sub 0/ obtained from the in vitro and in vivo irradiation were 200 and 198 rad, respectively. The dose-response curve had a wide shoulder, and the values of D/sub q/ for both mouse and hamster colony-forming cells were 97 and 141 rad, respectively.

• Research Organization: Washington Univ. School of Medicine, St. Louis, MO
• OSTI ID: 5654608
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 89:2; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560122* -- Radiation Effects on Cells-- Internal Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AZINES
COLONY FORMATION
CONNECTIVE TISSUE CELLS
HAMSTERS
HETEROCYCLIC COMPOUNDS
IN VITRO
LABELLED COMPOUNDS
MACROPHAGES
MAMMALS
MICE
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHAGOCYTES
PYRIMIDINES
RADIOSENSITIVITY
RIBOSIDES
RODENTS
SOMATIC CELLS
THYMIDINE
TRITIUM COMPOUNDS
VERTEBRATES