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Effects of dose rate and dose fractionation of irradiation on pulmonary alveolar macrophage colony-forming cells

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3576580· OSTI ID:5322123
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The authors have studied the effects of dose rate and dose fractionation on murine pulmonary alveolar macrophage colony-forming cells (AL-CFC). The dose-response curve of AL-CFC to ionizing irradiation has a D/sub q/ of about 100 rad, reflecting the cells' ability to repair sublethal damage. For comparison, they investigated the effect of dose schedule on the committed bone marrow stem cells for both granulocytes and monocytes (GM-CFC) since their dose-response curve has a very small shoulder. A significant dose rate effect was observed. To study the effect of dose fractionation, a total of 600 rad was given either as a single fraction, three fractions of 200 rad on 3 consecutive days, or six fractions of 100 rad in 3 days. The most dramatic effect was seen in the group that received six 100-rad fractions. No reduction in the number of AL-CFC was seen in this group. In sharp contrast, only a minimal dose schedule effect was observed with GM-CFC.
Research Organization:
Washington Univ. School of Medicine, St. Louis, MO
OSTI ID:
5322123
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 103:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
COLONY FORMATION
CONNECTIVE TISSUE CELLS
DOSE RATES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
FRACTIONATED IRRADIATION
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
IRRADIATION
LUNGS
MACROPHAGES
MAMMALS
MICE
ORGANS
PHAGOCYTES
RADIATION EFFECTS
RADIATIONS
RADIOSENSITIVITY EFFECTS
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
STEM CELLS
TISSUES
VERTEBRATES
X RADIATION