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Dose- and time-related quantitative and qualitative alterations in the granulocyte/macrophage progenitor cell (GM-CFC) compartment of dogs after total-body irradiation

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3576240· OSTI ID:6782445
; ;

The effects of single-dose total-body X irradiation (TBI) on the granulocyte/macrophage progenitor cell (GM-CFC) population in bone marrow and blood of dogs were studied for dose levels of 0.78 and 1.57 Gy up to 164 days after irradiation. The blood GM-CFC concentration per milliliter was depressed in the first 7 days in a dose-dependent fashion to 5-16% of normal after 0.78 Gy and to between 0.7 and 5% after 1.57 Gy. The bone marrow GM-CFC concentration per 10/sub 5/ mononuclear cells, on the other hand, was initially reduced to about 45% of the average pre-irradiation value after 0.78 Gy and to 23% after 1.57 Gy. The regeneration within the first 30 to 40 days after TBI of the blood granulocyte values and the repopulation of the bone marrow GM-CFC compartment was associated with both a dose-dependent increase in the S-phase fraction of the bone marrow GM-CFC and a dose-dependent increase in colony-stimulating activity (CSA) in the serum.

Research Organization:
Univ. of Ulm, West Germany
OSTI ID:
6782445
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 98:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD COUNT
BODY
BODY FLUIDS
BONE MARROW
COMPARTMENTS
CONNECTIVE TISSUE CELLS
DATA
DOGS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
EXTERNAL IRRADIATION
HEMATOPOIETIC SYSTEM
INFORMATION
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
MACROPHAGES
MAMMALS
MATERIALS
NUMERICAL DATA
ORGANS
PHAGOCYTES
POPULATION DYNAMICS
RADIATION EFFECTS
RADIATIONS
SOMATIC CELLS
TISSUES
VERTEBRATES
WHOLE-BODY IRRADIATION
X RADIATION