Hematological effects of unilateral and bilateral exposures of dogs to 300-kVp X rays

Journal Article · Sun Jul 01 00:00:00 EDT 1990 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577651· OSTI ID:6639744

Baltschukat, K; Nothdurft, W ^[1]

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1. Univ. of Ulm (Germany, F.R.)

Accidental exposures to ionizing radiation from external sources usually result in an inhomogeneous dose distribution rather than a homogeneous total-body irradiation (TBI). To study the hematological effects of an inhomogeneous dose distribution, dogs were unilaterally exposed to a beam of 300 kVp X rays (HVL = 3.8 mm Cu) with their left side directed to the source. The entrance and exit surface doses were 3.8 Gy and 0.9 Gy, respectively. Dose measurements performed in bone marrow spaces of various bones revealed a maximum of 3.1 Gy in the head of the left humerus and a minimum of 0.9 Gy in the right iliac crest. Based on survival for granulocyte-macrophage progenitor cells (GM-CFC) determined in different bone marrow sites 24 h after the exposure, the dose-dependent reduction ranged from 0.44 to 16% of the control values. The regeneration of the GM-CFC compartments in the various bone marrow spaces showed patterns which were independent of each other up to Day 28. Values were normal again at Day 125 after exposure. For comparative purposes, three dogs were exposed bilaterally to achieve a homogeneous dose distribution. They received a TBI of 2.4 Gy, which according to previous calculations should have caused the same systemic damage to the GM-CFC compartment as the unilateral exposure. The peripheral blood cell changes, including the GM-CFC, and the colony stimulating activity in the serum showed a similar pattern for both exposures. These findings support the hypothesis that the overall survival fraction of progenitor cells in the bone marrow is the main determinant of the blood cell changes, independent of the anatomical distribution.

• OSTI ID: 6639744
• Journal Information: Radiation Research; (USA), Vol. 123:1; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW
BIOLOGICAL RADIATION EFFECTS
DOGS
DOSE-RESPONSE RELATIONSHIPS
LEUKOCYTES
MACROPHAGES
RADIATION DOSE DISTRIBUTIONS
RADIATION DOSES
STEM CELLS
SURVIVAL TIME
X RADIATION
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DOSES
ELECTROMAGNETIC RADIATION
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
MAMMALS
MATERIALS
ORGANS
PHAGOCYTES
RADIATION EFFECTS
RADIATIONS
SOMATIC CELLS
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals