Prenatal and neonatal irradiation in dogs: hematologic and hematopoietic responses
Hematologic and hematopoietic responses were evaluated in beagle dogs following a single prenatal (35 days gestation) or neonatal (10 days postpartum) exposure to 1.5 Gy /sup 60/Co gamma radiation. Hematopoiesis was studied by the in vitro culture of bone marrow granulocyte-macrophage progenitors (CFU-GM). Prenatally irradiated dogs exhibited a progressive, significant reduction in CFU-GM which was accompanied by decreases in peripheral blood leukocytes up to 24 weeks of age. Dogs which were neonatally irradiated also demonstrated a significant reduction in CFU-GM which was accompanied by significant alterations in peripheral white and red blood cell parameters. This was transient, however, and these dogs showed partial recovery of CFU-GM and hematologic parameter by 24 weeks of age. The persistent CFU-GM deficit in prenatally irradiated dogs suggests a relatively greater sensitivity of fetal marrow as compared to neonatal bone marrow for long-term damage by ionizing radiation.
- Research Organization:
- Colorado State Univ., Fort Collins
- OSTI ID:
- 5467443
- Journal Information:
- Radiat. Res.; (United States), Vol. 112:3
- Country of Publication:
- United States
- Language:
- English
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Effects of prenatal irradiation on fetal, neonate, and young adult murine hemopoiesis
Effects of prenatal irradiation on fetal, neonate, and young adult murine hemopoiesis
Related Subjects
BONE MARROW
RADIOSENSITIVITY
HEMATOPOIETIC SYSTEM
BIOLOGICAL RADIATION EFFECTS
ACUTE EXPOSURE
BEAGLES
COBALT 60
GAMMA RADIATION
LEUKOCYTES
PREGNANCY
PRENATAL EXPOSURE
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
COBALT ISOTOPES
DOGS
ELECTROMAGNETIC RADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals