Rat liver foci study on coexposure with 50 Hz magnetic fields and known carcinogens
Journal Article
·
· Bioelectromagnetics (New York); (United States)
- National Inst. of Occupational Health, Solna (Sweden)
- National Inst. of Occupational Health, Umeaa (Sweden)
A study was performed to investigate possible interactions by magnetic fields (MF) with the processes of initiation and promotion of chemically induced preneoplastic lesions in rat liver. Male Sprague-Dawley rats were subjected to a 70% partial hepatectomy followed after 24 h by i.p. injection of diethylnitrosamine (DENA) as a tumor initiator. Starting one week after the DENA-treatment phenobarbital (PB) was given to promote growth of enzymatically altered foci of liver cells. MF was applied immediately after the partial hepatectomy and continued until sacrifice after 12 weeks of PB exposure. Homogeneous horizontal AC magnetic fields with a frequency of 50Hz and flux densities of 0.5 [mu]T or 0.5 mT were used. The rats coexposed with MF and DENA plus PB did not gain weight as much as the rats exposed to the chemical agents only. The MF-exposure also resulted in a slight reduction in size and numbers of the focal lesions. The results suggest an interaction of MF with the processes of chemical carcinogenesis either as a result of stress or depending on effects on the proliferation of preneoplastic cells.
- OSTI ID:
- 6431637
- Journal Information:
- Bioelectromagnetics (New York); (United States), Journal Name: Bioelectromagnetics (New York); (United States) Vol. 14:1; ISSN 0197-8462; ISSN BLCTDO
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560300 -- Chemicals Metabolism & Toxicology
560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL CELLS
ANIMALS
CARCINOGENESIS
CELL PROLIFERATION
ELECTROMAGNETIC FIELDS
HEPATECTOMY
LIVER CELLS
MAMMALS
MEDICINE
NITROSAMINES
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
RATS
RODENTS
SOMATIC CELLS
SURGERY
TUMOR CELLS
VERTEBRATES
560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL CELLS
ANIMALS
CARCINOGENESIS
CELL PROLIFERATION
ELECTROMAGNETIC FIELDS
HEPATECTOMY
LIVER CELLS
MAMMALS
MEDICINE
NITROSAMINES
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
RATS
RODENTS
SOMATIC CELLS
SURGERY
TUMOR CELLS
VERTEBRATES