Early appearance of histochemically altered hepatocyte foci and liver tumors in female rats treated with carcinogens one day after birth

Journal Article · Thu Jan 01 04:00:00 EST 1981 · Carcinogenesis (N.Y.); (United States)

DOI:https://doi.org/10.1093/carcin/2.5.463· OSTI ID:5335783

Peraino, C; Staffeldt, E F; Ludeman, V A

A single i.p. injection of diethylnitrosamine (DEN) or benzo(a)pyrene (BAP) in 1-day-old female rats produced a high incidence of ..gamma..-glutamyltranspeptidase-(GGT)- positive hepatocyte foci within 4 weeks after the rats were weaned onto a 0.05% phenobarbital diet; the injection of benzo(e)pyrene did not produce foci under these conditions. Liver tumors appeared in rats treated with DEN within 8 weeks after weaning and in BAP-treated rats within 16 weeks after weaning. The results suggest that the treatment protocol used in this study may increase the utility of the liver tumorigenesis model as a broadly applicable in vitro system for the rapid detection of tumorigenic potential in environmental contaminants.

• Research Organization: Argonne National Lab., IL
• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 5335783
• Journal Information: Carcinogenesis (N.Y.); (United States), Journal Name: Carcinogenesis (N.Y.); (United States) Vol. 2:5; ISSN CRNGD
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMAL CELLS
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
CONDENSED AROMATICS
DIAGNOSIS
DIGESTIVE SYSTEM
DISEASES
ENZYMES
GLANDS
HYDROCARBONS
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
LIVER
MAMMALS
NEONATES
NEOPLASMS
NITROSAMINES
NITROSO COMPOUNDS
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
RATS
RODENTS
VERTEBRATES