Inhibition by complex organic mixtures of benzo(a)pyrene- and diethylnitrosamine initiation of preneoplastic changes in rat liver
Technical Report
·
OSTI ID:5321955
Previous studies using the mouse skin initiation-promotion model have shown that initiating activities of pure carvinogens are decreased when they are applied simultaneously with complex coal-derived mixtures. In the present study the number of altered hepatocyte foci which stained for gamma glutamyl transpeptidase (GGT) were determined in rats that were neonatally treated with an initiator, followed by promotion with dietary phenobarbitol for 8 weeks after weaning. Initiators were either benzo(a)pyrene (BaP), diethylnitrosamine (DEN), or complex coal-derived mixtures. Although the compled organic mixtures contained known carcinogens, their initiating activities were low at the doses used. Co-administration of complex, coal-derived mixtures with BaP or DEN decreased the response to both carcinogens. Together with data from studies with the skin initiation-promotion model, the results suggest that tumorigenic activities of coal-derived complex organic mixtures are less than predicted from the content of carcinogenic components. 20 refs., 2 tabs.
- Research Organization:
- Pacific Northwest Lab., Richland, WA (USA). Biology and Chemistry Dept.; Argonne National Lab., IL (USA). Biological and Medical Research Div.
- DOE Contract Number:
- AC06-76RL01830
- OSTI ID:
- 5321955
- Report Number(s):
- PNL-SA-13204; ON: DE86015539
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AROMATICS
BENZOPYRENE
CARCINOGENESIS
CELL TRANSFORMATIONS
COAL LIQUIDS
COAL TAR
CONDENSED AROMATICS
ENZYMES
FLUIDS
HYDROCARBONS
LIQUIDS
MAMMALS
NITROSAMINES
NITROSO COMPOUNDS
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OTHER ORGANIC COMPOUNDS
PATHOGENESIS
RATS
RODENTS
SYNERGISM
TAR
TRANSFERASES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AROMATICS
BENZOPYRENE
CARCINOGENESIS
CELL TRANSFORMATIONS
COAL LIQUIDS
COAL TAR
CONDENSED AROMATICS
ENZYMES
FLUIDS
HYDROCARBONS
LIQUIDS
MAMMALS
NITROSAMINES
NITROSO COMPOUNDS
ONCOGENIC TRANSFORMATIONS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OTHER ORGANIC COMPOUNDS
PATHOGENESIS
RATS
RODENTS
SYNERGISM
TAR
TRANSFERASES
VERTEBRATES